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TCP11 t-complex 11 [ Homo sapiens (human) ]

Gene ID: 6954, updated on 3-Apr-2024

Summary

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Official Symbol
TCP11provided by HGNC
Official Full Name
t-complex 11provided by HGNC
Primary source
HGNC:HGNC:11658
See related
Ensembl:ENSG00000124678 MIM:186982; AllianceGenome:HGNC:11658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPPR; D6S230E
Summary
Predicted to be involved in several processes, including protein kinase A signaling; regulation of cAMP-mediated signaling; and regulation of sperm capacitation. Located in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 154.9) See more
Orthologs
mouse all
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Genomic context

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See TCP11 in Genome Data Viewer
Location:
6p21.31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (35118075..35141339, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (34940885..34963547, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35085852..35109116, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:34855493-34856044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:34856778-34857660 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:34893897-34894070 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1A Neighboring gene NANOG hESC enhancer GRCh37_chr6:34960132-34960780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:34985455-34986058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24394 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35012271-35012922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35015552-35016400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35016401-35017247 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35025703-35026222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35027261-35027778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35036049-35036712 Neighboring gene NANOG hESC enhancer GRCh37_chr6:35037908-35038409 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35049025-35049696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35054004-35054504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35055243-35056070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35056071-35056896 Neighboring gene MPRA-validated peak5763 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24395 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:35115441-35116234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:35116235-35117028 Neighboring gene MPRA-validated peak5764 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr6:35152333-35152714 Neighboring gene Sharpr-MPRA regulatory region 4993 Neighboring gene uncharacterized LOC112267955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17084 Neighboring gene SCUBE3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17085 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:35211069-35212268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24396 Neighboring gene signal peptide, CUB domain and EGF like domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene]. Ma YX, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2003 Apr. PMID 12905703
  2. [Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene]. Ma YX, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003 Feb. PMID 12545228
  3. Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide. Ma Y, et al. Mol Hum Reprod, 2002 Jan. PMID 11756566
  4. Isolation and characterisation of a testis-expressed developmentally regulated gene from the distal inversion of the mouse t-complex. Mazarakis ND, et al. Development, 1991 Feb. PMID 1893875
  5. Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology. Liu Y, et al. Tohoku J Exp Med, 2011 Jun. PMID 21597245

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells.
    Title: Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells.
  2. These results suggest that TCP11 may be responsible for sperm tail morphology and motility.
    Title: Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
  4. Results suggest that TCP11 gene is important in sperm function and fertility.
    Title: Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0229, MGC111103

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in germ cell development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein kinase A signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sperm capacitation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
T-complex protein 11 homolog
Names
fertilization-promoting peptide receptor
t-complex 11 (a murine tcp homolog)
t-complex 11 homolog
t-complex 11, testis-specific
testis secretory sperm-binding protein Li 222n

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261817.2 → NP_001248746.2  T-complex protein 11 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL138721
    Consensus CDS
    CCDS59018.2
    UniProtKB/TrEMBL
    A0A6E1WXZ9, B7ZAT8
    Related
    ENSP00000404479.3, ENST00000444780.7
    Conserved Domains (1) summary
    pfam05794
    Location:53 → 482
    Tcp11; T-complex protein 11

  2. NM_001261818.2 → NP_001248747.1  T-complex protein 11 homolog isoform 4

    See identical proteins and their annotated locations for NP_001248747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AF536533, AK301975, BF507838
    Consensus CDS
    CCDS59017.1
    UniProtKB/TrEMBL
    A0A140VK95
    Related
    ENSP00000363085.4, ENST00000373974.8
    Conserved Domains (1) summary
    pfam05794
    Location:29 → 451
    Tcp11; T-complex protein 11

  3. NM_001261819.2 → NP_001248748.1  T-complex protein 11 homolog isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AF260330, AK302022, DC396535
    Consensus CDS
    CCDS59016.1
    UniProtKB/TrEMBL
    B7ZAT8
    Related
    ENSP00000402816.2, ENST00000412155.6
    Conserved Domains (1) summary
    pfam05794
    Location:24 → 446
    Tcp11; T-complex protein 11

  4. NM_001261820.2 → NP_001248749.1  T-complex protein 11 homolog isoform 6

    See identical proteins and their annotated locations for NP_001248749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, includes an alternate internal exon in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (6), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF536532, AF536533
    Consensus CDS
    CCDS59015.1
    UniProtKB/TrEMBL
    B7ZAT8
    Related
    ENSP00000478603.1, ENST00000611141.4
    Conserved Domains (1) summary
    pfam05794
    Location:1 → 424
    Tcp11; T-complex protein 11

  5. NM_001261821.2 → NP_001248750.1  T-complex protein 11 homolog isoform 6

    See identical proteins and their annotated locations for NP_001248750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences, including the use of a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (6), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF536533, BC090050
    Consensus CDS
    CCDS59015.1
    UniProtKB/TrEMBL
    B7ZAT8
    Conserved Domains (1) summary
    pfam05794
    Location:1 → 424
    Tcp11; T-complex protein 11

  6. NM_001366323.2 → NP_001353252.1  T-complex protein 11 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Consensus CDS
    CCDS59015.1
    UniProtKB/TrEMBL
    B7ZAT8
    Related
    ENSP00000415320.2, ENST00000418521.6
    Conserved Domains (1) summary
    pfam05794
    Location:1 → 424
    Tcp11; T-complex protein 11

  7. NM_001366324.2 → NP_001353253.1  T-complex protein 11 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Consensus CDS
    CCDS4799.1
    UniProtKB/TrEMBL
    B7ZAT8
    Conserved Domains (1) summary
    pfam05794
    Location:15 → 425
    Tcp11; T-complex protein 11

  8. NM_001366325.2 → NP_001353254.1  T-complex protein 11 homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL138721

  9. NM_001366326.2 → NP_001353255.1  T-complex protein 11 homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL138721

  10. NM_001366327.2 → NP_001353256.1  T-complex protein 11 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Conserved Domains (1) summary
    pfam05794
    Location:1 → 346
    Tcp11; T-complex protein 11

  11. NM_001366328.2 → NP_001353257.1  T-complex protein 11 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Conserved Domains (1) summary
    pfam05794
    Location:1 → 346
    Tcp11; T-complex protein 11

  12. NM_001366329.2 → NP_001353258.1  T-complex protein 11 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Conserved Domains (1) summary
    pfam05794
    Location:1 → 346
    Tcp11; T-complex protein 11

  13. NM_001366330.2 → NP_001353259.1  T-complex protein 11 homolog isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL138721

  14. NM_001366331.2 → NP_001353260.1  T-complex protein 11 homolog isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL138721

  15. NM_001366332.2 → NP_001353261.1  T-complex protein 11 homolog isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL138721
    UniProtKB/TrEMBL
    H0Y8T8
    Related
    ENSP00000422105.1, ENST00000502480.5

  16. NM_001370687.1 → NP_001357616.1  T-complex protein 11 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL138721
    Consensus CDS
    CCDS47413.2
    UniProtKB/Swiss-Prot
    B2RCE9, B3KQ27, B7Z7B5, B7Z7G1, B7Z7H4, B7Z7S8, E7EP29, J3KNG1, Q8NF85, Q8WWU5, Q9NQZ9, Q9NR39
    UniProtKB/TrEMBL
    A0A140VK95
    Related
    ENSP00000308708.6, ENST00000311875.11
    Conserved Domains (1) summary
    pfam05794
    Location:58 → 487
    Tcp11; T-complex protein 11

  17. NM_018679.6 → NP_061149.1  T-complex protein 11 homolog isoform 2

    See identical proteins and their annotated locations for NP_061149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, including the use of an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF536533
    Consensus CDS
    CCDS4799.1
    UniProtKB/TrEMBL
    B7ZAT8
    Related
    ENSP00000244645.3, ENST00000244645.7
    Conserved Domains (1) summary
    pfam05794
    Location:15 → 425
    Tcp11; T-complex protein 11

RNA

  1. NR_158873.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL138721

  2. NR_158874.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL138721

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    35118075..35141339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514832.2 → XP_011513134.1  T-complex protein 11 homolog isoform X1

    See identical proteins and their annotated locations for XP_011513134.1

    Conserved Domains (1) summary
    pfam05794
    Location:1 → 346
    Tcp11; T-complex protein 11

  2. XM_047419278.1 → XP_047275234.1  T-complex protein 11 homolog isoform X1

  3. XM_011514830.3 → XP_011513132.2  T-complex protein 11 homolog isoform X2

    UniProtKB/TrEMBL
    B7Z7Q2
    Conserved Domains (1) summary
    pfam05794
    Location:71 → 439
    Tcp11; T-complex protein 11

  4. XM_047419277.1 → XP_047275233.1  T-complex protein 11 homolog isoform X5

  5. XM_047419276.1 → XP_047275232.1  T-complex protein 11 homolog isoform X4

  6. XM_047419275.1 → XP_047275231.1  T-complex protein 11 homolog isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    34940885..34963547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356275.1 → XP_054212250.1  T-complex protein 11 homolog isoform X6

  2. XM_054356276.1 → XP_054212251.1  T-complex protein 11 homolog isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWU5.1 GenPept UniProtKB/Swiss-Prot:Q8WWU5

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