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Dnase1l1 deoxyribonuclease 1-like 1 [ Mus musculus (house mouse) ]

Gene ID: 69537, updated on 11-Apr-2024

Summary

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Official Symbol
Dnase1l1provided by MGI
Official Full Name
deoxyribonuclease 1-like 1provided by MGI
Primary source
MGI:MGI:109628
See related
Ensembl:ENSMUSG00000019088 AllianceGenome:MGI:109628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G4.8; Dnasex; Dnl1ll; Dnase1ll; 2310005K03Rik
Summary
Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process, endonucleolytic. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human DNASE1L1 (deoxyribonuclease 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 15.2), bladder adult (RPKM 10.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Dnase1l1 in Genome Data Viewer
Location:
X A7.3; X 37.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73316823..73325939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74273217..74282333, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene emerin Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47366 Neighboring gene ribosomal protein L10 Neighboring gene small nucleolar RNA, H/ACA box 70 Neighboring gene microRNA 7091 Neighboring gene predicted gene 14846 Neighboring gene tafazzin, phospholipid-lysophospholipid transacylase Neighboring gene STARR-positive B cell enhancer ABC_E7694 Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 1 Neighboring gene GDP dissociation inhibitor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells. Mohan Kumar D, et al. PLoS Pathog, 2013. PMID 24098122, Free PMC Article
  2. Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region. Pergolizzi R, et al. Gene, 1996 Feb 12. PMID 8654957
  3. Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X. Shiokawa D, et al. Biochem J, 2005 Dec 15. PMID 16107205, Free PMC Article
  4. A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Rivella S, et al. Genomics, 1995 Aug 10. PMID 7490070
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast two-hybrid screening revealed that DNase X, a glycosylphosphatidyl inositol-anchored mammalian cell-surface protein binds EtpE-C.
    Title: Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyribonuclease I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
deoxyribonuclease-1-like 1
Names
DNase I-like 1
DNase X
deoxyribonuclease I-like 1
NP_001165625.2
NP_001357716.1
NP_081385.2
XP_006528335.1
XP_006528336.1
XP_017174102.1
XP_017174103.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172154.2 → NP_001165625.2  deoxyribonuclease-1-like 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL807376
    Consensus CDS
    CCDS30223.1
    UniProtKB/Swiss-Prot
    Q3UD56, Q9D7J6
    UniProtKB/TrEMBL
    A0A158SIT2, A0A6I8MWW4
    Related
    ENSMUSP00000075218.4, ENSMUST00000075821.10
    Conserved Domains (1) summary
    cl00490
    Location:9 → 271
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_001370787.1 → NP_001357716.1  deoxyribonuclease-1-like 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL807376
    UniProtKB/Swiss-Prot
    Q3UD56, Q9D7J6
    UniProtKB/TrEMBL
    A0A158SIT2
    Conserved Domains (1) summary
    cl00490
    Location:9 → 245
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. NM_027109.3 → NP_081385.2  deoxyribonuclease-1-like 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL807376
    Consensus CDS
    CCDS30223.1
    UniProtKB/Swiss-Prot
    Q3UD56, Q9D7J6
    UniProtKB/TrEMBL
    A0A158SIT2, A0A6I8MWW4
    Related
    ENSMUSP00000159292.2, ENSMUST00000239458.2
    Conserved Domains (1) summary
    cl00490
    Location:9 → 271
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73316823..73325939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528273.5 → XP_006528336.1  deoxyribonuclease-1-like 1 isoform X2

    Conserved Domains (1) summary
    cl00490
    Location:27 → 191
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. XM_006528272.5 → XP_006528335.1  deoxyribonuclease-1-like 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UD56, Q9D7J6
    UniProtKB/TrEMBL
    A0A158SIT2
    Conserved Domains (1) summary
    cl00490
    Location:27 → 234
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. XM_017318613.3 → XP_017174102.1  deoxyribonuclease-1-like 1 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:63 → 161
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. XM_017318614.3 → XP_017174103.1  deoxyribonuclease-1-like 1 isoform X4

    Conserved Domains (1) summary
    cl00490
    Location:27 → 152
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7J6.3 GenPept UniProtKB/Swiss-Prot:Q9D7J6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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