Ttc9 tetratricopeptide repeat domain 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttc9provided by MGI
Official Full Name: tetratricopeptide repeat domain 9provided by MGI
Primary source: MGI:MGI:1916730
See related: Ensembl:ENSMUSG00000042734 AllianceGenome:MGI:1916730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a protein that contains three tetratricopeptide repeats. The human gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Sep 2015]
Expression: Biased expression in cerebellum adult (RPKM 8.8), CNS E18 (RPKM 8.2) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 37.85 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (81678023..81714331)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (81631249..81667557)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TTC9A modulates the anxiety-related behaviors through modulation of estrogen action on the serotonergic system in the dorsal raphe nucleus.
Title: Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice.
Together with the observation that TTC9A is a direct ERalpha target gene, this study proposes that the fall and rise of TTC9A levels during lactation and involution is caused by the changes of ERalpha activity that is in turn regulated by the factors in the microenvironment.
Title: The local microenvironment instigates the regulation of mammary tetratricopeptide repeat domain 9A during lactation and involution through local regulation of the activity of estrogen receptor α.
Though the function of TTC9 is not yet clear, the susceptibility of its protein level to biological and chemical agents suggests that TTC9 is a biologically significant protein.
Title: Identification of tetratricopeptide repeat domain 9, a hormonally regulated protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

D12Mit214 (e-PCR), detects polymorphism
- UniSTS:126769

RH130867 (e-PCR)
- UniSTS:214151

AI853559 (e-PCR)
- UniSTS:164506

AI429215 (e-PCR)
- UniSTS:180420

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tetratricopeptide repeat protein 9A

Names: TPR repeat protein 9A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.