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Dennd6b DENN domain containing 6B [ Mus musculus (house mouse) ]

Gene ID: 69440, updated on 5-Mar-2024

Summary

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Official Symbol
Dennd6bprovided by MGI
Official Full Name
DENN domain containing 6Bprovided by MGI
Primary source
MGI:MGI:1916690
See related
Ensembl:ENSMUSG00000015377 AllianceGenome:MGI:1916690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam116b; 1700027J05Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in endosome. Predicted to be active in recycling endosome. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human DENND6B (DENN domain containing 6B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 33.8), cerebellum adult (RPKM 32.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Dennd6b in Genome Data Viewer
Location:
15 E3; 15 44.7 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89066416..89080793, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89182213..89198427, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 11 Neighboring gene plexin B2 Neighboring gene microRNA 7118 Neighboring gene STARR-seq mESC enhancer starr_39459 Neighboring gene microRNA 6958 Neighboring gene STARR-positive B cell enhancer ABC_E3151 Neighboring gene STARR-positive B cell enhancer ABC_E4146 Neighboring gene protein phosphatase 6, regulatory subunit 2 Neighboring gene SET binding factor 1 Neighboring gene microRNA 6959

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein DENND6B
Names
DENN domain-containing protein 6B
DENN/MADD domain containing 6B
family with sequence similarity 116, member B
protein FAM116B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027081.3 → NP_081357.2  protein DENND6B

    See identical proteins and their annotated locations for NP_081357.2

    Status: VALIDATED

    Source sequence(s)
    AK006427, BB658928, BC058958, BQ444357, BY252285
    Consensus CDS
    CCDS57000.1
    UniProtKB/Swiss-Prot
    B2RSU3, Q9D9V7
    Related
    ENSMUSP00000077978.8, ENSMUST00000078953.9
    Conserved Domains (2) summary
    pfam08616
    Location:250 → 356
    SPA; Stabilization of polarity axis
    cl11519
    Location:151 → 311
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89066416..89080793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248748.1 → XP_030104608.1  protein DENND6B isoform X3

    Conserved Domains (2) summary
    pfam08616
    Location:126 → 232
    SPA; Stabilization of polarity axis
    cl11519
    Location:28 → 187
    DENN; DENN (AEX-3) domain

  2. XM_030248747.2 → XP_030104607.1  protein DENND6B isoform X2

    Conserved Domains (2) summary
    pfam08616
    Location:153 → 259
    SPA; Stabilization of polarity axis
    cl11519
    Location:54 → 214
    DENN; DENN (AEX-3) domain

  3. XM_030248744.2 → XP_030104604.1  protein DENND6B isoform X1

    Conserved Domains (2) summary
    pfam08616
    Location:223 → 329
    SPA; Stabilization of polarity axis
    cl11519
    Location:125 → 284
    DENN; DENN (AEX-3) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9V7.3 GenPept UniProtKB/Swiss-Prot:Q9D9V7

Gene LinkOut

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