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ZNF354A zinc finger protein 354A [ Homo sapiens (human) ]

Gene ID: 6940, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF354Aprovided by HGNC
Official Full Name
zinc finger protein 354Aprovided by HGNC
Primary source
HGNC:HGNC:11628
See related
Ensembl:ENSG00000169131 MIM:602444; AllianceGenome:HGNC:11628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EZNF; HKL1; KID1; KID-1; TCF17; HEL104
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. Biomarker of in situ carcinoma and seminoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 5.1), thyroid (RPKM 4.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
5q35.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (178711512..178730659, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (179263543..179282761, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (178138513..178157660, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 2 receptor 2 pseudogene Neighboring gene Myb/SANT DNA binding domain containing 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178150344-178150844 Neighboring gene MPRA-validated peak5604 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16723 Neighboring gene acetoacetyl-CoA synthetase pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4957 Neighboring gene Sharpr-MPRA regulatory region 5461 Neighboring gene coiled-coil domain containing 86 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. Bugert P, et al. Int J Cancer, 2000 Jun 15. PMID 10842194
  2. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. Omori Y, et al. Cytogenet Cell Genet, 1997. PMID 9465904
  3. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. Jacob AN, et al. Somat Cell Mol Genet, 1998 Mar. PMID 9919311
  4. Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Witzgall R, et al. Mol Cell Biol, 1993 Mar. PMID 8382778, Free PMC Article
  5. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Kim SS, et al. Proc Natl Acad Sci U S A, 1996 Dec 24. PMID 8986806, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 354A (ZNF354A; TCF17) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of zinc finger protein 354A (ZNF354A; TCF17) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 354A
Names
epididymis luminal protein 104
transcription factor 17
zinc finger protein eZNF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324339.2 → NP_001311268.1  zinc finger protein 354A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113348, EU794664
    UniProtKB/TrEMBL
    V9HWI2
    Conserved Domains (3) summary
    COG5048
    Location:156 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:454 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:326 → 351
    zf-H2C2_2; Zinc-finger double domain

  2. NM_005649.3 → NP_005640.2  zinc finger protein 354A isoform 1

    See identical proteins and their annotated locations for NP_005640.2

    Status: VALIDATED

    Source sequence(s)
    AC113348, AF116030, BC036517, BU685427
    Consensus CDS
    CCDS4438.1
    UniProtKB/Swiss-Prot
    O60765, Q9UNJ8
    UniProtKB/TrEMBL
    V9HWI2
    Related
    ENSP00000337122.2, ENST00000335815.7
    Conserved Domains (5) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:198 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:368 → 393
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    178711512..178730659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009791.2 → XP_016865280.1  zinc finger protein 354A isoform X1

    UniProtKB/Swiss-Prot
    O60765, Q9UNJ8
    UniProtKB/TrEMBL
    V9HWI2
    Conserved Domains (5) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:198 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:368 → 393
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047417644.1 → XP_047273600.1  zinc finger protein 354A isoform X1

    UniProtKB/Swiss-Prot
    O60765, Q9UNJ8
    UniProtKB/TrEMBL
    V9HWI2

  3. XM_011534645.3 → XP_011532947.1  zinc finger protein 354A isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:156 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:454 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:326 → 351
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    179263543..179282761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353337.1 → XP_054209312.1  zinc finger protein 354A isoform X1

    UniProtKB/Swiss-Prot
    O60765, Q9UNJ8
    UniProtKB/TrEMBL
    V9HWI2

  2. XM_054353338.1 → XP_054209313.1  zinc finger protein 354A isoform X1

    UniProtKB/Swiss-Prot
    O60765, Q9UNJ8
    UniProtKB/TrEMBL
    V9HWI2

  3. XM_054353339.1 → XP_054209314.1  zinc finger protein 354A isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60765.2 GenPept UniProtKB/Swiss-Prot:O60765

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