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Dnajb13 DnaJ heat shock protein family (Hsp40) member B13 [ Mus musculus (house mouse) ]

Gene ID: 69387, updated on 11-Apr-2024

Summary

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Official Symbol
Dnajb13provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member B13provided by MGI
Primary source
MGI:MGI:1916637
See related
Ensembl:ENSMUSG00000030708 AllianceGenome:MGI:1916637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsarg; 1700014P03Rik
Summary
Predicted to enable chaperone binding activity and unfolded protein binding activity. Predicted to be involved in axonemal central apparatus assembly and chaperone cofactor-dependent protein refolding. Predicted to act upstream of or within cell projection organization. Located in axoneme and sperm connecting piece. Is expressed in several structures, including brain ventricle and choroid plexus; ventricular layer; and white fat. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 34. Orthologous to human DNAJB13 (DnaJ heat shock protein family (Hsp40) member B13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 160.4) and ovary adult (RPKM 6.8) See more
Orthologs
human all
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Genomic context

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Location:
7 E2; 7 54.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100152218..100182834, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100503011..100514815, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene uncoupling protein 3 (mitochondrial, proton carrier) Neighboring gene STARR-positive B cell enhancer mm9_chr7:107641658-107641958 Neighboring gene STARR-positive B cell enhancer ABC_E2244 Neighboring gene uncoupling protein 2 (mitochondrial, proton carrier) Neighboring gene STARR-seq mESC enhancer starr_19669 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107685672-107685781 Neighboring gene predicted gene, 39058 Neighboring gene cytochrome c oxidase assembly factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice. Oji A, et al. Sci Rep, 2016 Aug 17. PMID 27530713, Free PMC Article
  2. DNAJB13 is a radial spoke protein of mouse '9+2' axoneme. Guan J, et al. Reprod Domest Anim, 2010 Dec. PMID 19919626
  3. [Molecular cloning of mTSARG3 gene related to apoptosis in mouse spermatogenic cells]. Liu G, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003 Dec. PMID 14673507
  4. Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development. Guan J, et al. BMC Dev Biol, 2009 Mar 19. PMID 19298648, Free PMC Article
  5. [Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells]. Liu G, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2003 Apr. PMID 12673577

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that DNAJB13 participates in spermiogenesis and the motility of mature spermatozoa.
    Title: DNAJB13, a type II HSP40 family member, localizes to the spermatids and spermatozoa during mouse spermatogenesis.
  2. By multi-tissue reverse transcription polymerase chain reaction, we found that Dnajb13 gene was expressed not only in the testis but also in several other ciliated cell-containing tissues like brain, lung and oviduct.
    Title: DNAJB13 is a radial spoke protein of mouse '9+2' axoneme.
  3. The interaction of DNAJB13 with SEPT4 in vitro and its spatiotemporal association with the annulus during sperm flagellum development suggest that DNAJB13 may be involved in assembling the annulus structure.
    Title: Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development.
  4. DNAJB13 might be involved in assembly and stability of axoneme during sperm flagellum development.
    Title: A heat-shock protein 40, DNAJB13, is an axoneme-associated component in mouse spermatozoa.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axonemal central apparatus assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cilium movement involved in extracellular fluid movement IC
Inferred by Curator
more info
 PubMed 
involved_in flagellated sperm motility IC
Inferred by Curator
more info
 PubMed 
involved_in mating IC
Inferred by Curator
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in 9+2 motile cilium IC
Inferred by Curator
more info
 PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
part_of radial spoke IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm connecting piece IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IC
Inferred by Curator
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 13
Names
DnaJ (Hsp40) related, subfamily B, member 13
spermatogenesis apoptosis-related protein
testis and spermatogenesis cell-related protein 6
testis spermatocyte apoptosis-related gene 6 protein
testis spermatogenesis apoptosis-related gene 3 protein
testis spermatogenesis apoptosis-related gene 6 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153527.3 → NP_705755.2  dnaJ homolog subfamily B member 13

    See identical proteins and their annotated locations for NP_705755.2

    Status: VALIDATED

    Source sequence(s)
    AC117215
    Consensus CDS
    CCDS21499.1
    UniProtKB/Swiss-Prot
    Q80Y75, Q8CJA2
    UniProtKB/TrEMBL
    A0A171EBK9
    Related
    ENSMUSP00000147019.2, ENSMUST00000207405.2
    Conserved Domains (3) summary
    cd10747
    Location:138 → 302
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1 → 312
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:4 → 65
    DnaJ; DnaJ domain

RNA

  1. NR_184865.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215
    Related
    ENSMUST00000154516.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100152218..100182834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153418.1 → XP_036009311.1  dnaJ homolog subfamily B member 13 isoform X2

    Conserved Domains (1) summary
    cd10747
    Location:31 → 157
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

  2. XM_006508184.3 → XP_006508247.1  dnaJ homolog subfamily B member 13 isoform X1

    UniProtKB/TrEMBL
    A0A171EBK9
    Conserved Domains (1) summary
    COG0484
    Location:18 → 307
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80Y75.1 GenPept UniProtKB/Swiss-Prot:Q80Y75

Gene LinkOut

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