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Zpbp2 zona pellucida binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 69376, updated on 5-Mar-2024

Summary

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Official Symbol
Zpbp2provided by MGI
Official Full Name
zona pellucida binding protein 2provided by MGI
Primary source
MGI:MGI:1916626
See related
Ensembl:ENSMUSG00000017195 AllianceGenome:MGI:1916626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZPBPL; 1700017D11Rik; 2610022C02Rik
Summary
Acts upstream of or within several processes, including binding activity of sperm to zona pellucida; membrane lipid metabolic process; and regulation of gene expression. Located in acrosomal vesicle and cell body. Part of zona pellucida receptor complex. Is expressed in lung. Orthologous to human ZPBP2 (zona pellucida binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 85.4) See more
Orthologs
human all
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Genomic context

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See Zpbp2 in Genome Data Viewer
Location:
11 D; 11 61.97 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98441923..98449491)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98551097..98558665)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene migration and invasion enhancer 1 Neighboring gene STARR-seq mESC enhancer starr_30668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320467-98320833 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320999-98321108 Neighboring gene growth factor receptor bound protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E11772 Neighboring gene IKAROS family zinc finger 3 Neighboring gene predicted gene, 25106 Neighboring gene STARR-positive B cell enhancer ABC_E7058 Neighboring gene VISTA enhancer mm503 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98388491-98388674 Neighboring gene STARR-positive B cell enhancer ABC_E8880 Neighboring gene STARR-positive B cell enhancer ABC_E8450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98412942-98413125 Neighboring gene predicted gene, 38981 Neighboring gene predicted gene, 31460

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance. Youssef M, et al. J Pharmacol Exp Ther, 2020 Jun. PMID 32273303
  2. Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock. Chang ML, et al. PLoS One, 2019. PMID 31560728, Free PMC Article
  3. Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion. Kanagaratham C, et al. Mamm Genome, 2018 Apr. PMID 29536159
  4. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Lin YN, et al. Mol Cell Biol, 2007 Oct. PMID 17664285, Free PMC Article
  5. The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. Dun MD, et al. J Biol Chem, 2011 Oct 21. PMID 21880732, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC107119

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in acrosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within binding of sperm to zona pellucida IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within membrane lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of zona pellucida receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zona pellucida-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166494.1 → NP_001159966.1  zona pellucida-binding protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001159966.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Variants 3 and 4 both encode isoform 3.
    Source sequence(s)
    AK006058, AL591125, BC089476
    Consensus CDS
    CCDS48903.1
    UniProtKB/TrEMBL
    A2A4X9
    Related
    ENSMUSP00000103133.2, ENSMUST00000107509.8
    Conserved Domains (1) summary
    pfam07354
    Location:1 → 272
    Sp38; Zona-pellucida-binding protein (Sp38)

  2. NM_001166495.1 → NP_001159967.1  zona pellucida-binding protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001159967.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Variants 3 and 4 both encode isoform 3.
    Source sequence(s)
    AK006058, AL591125, BC089476
    Consensus CDS
    CCDS48903.1
    UniProtKB/TrEMBL
    A2A4X9
    Related
    ENSMUSP00000103135.2, ENSMUST00000107511.8
    Conserved Domains (1) summary
    pfam07354
    Location:1 → 272
    Sp38; Zona-pellucida-binding protein (Sp38)

  3. NM_027061.2 → NP_081337.2  zona pellucida-binding protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_081337.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK006058, AL591125, BC089476
    Consensus CDS
    CCDS25353.1
    UniProtKB/Swiss-Prot
    A2A4Y0, Q6X785, Q6X786, Q9DA91
    UniProtKB/TrEMBL
    A2A4X9
    Related
    ENSMUSP00000017339.6, ENSMUST00000017339.12
    Conserved Domains (1) summary
    pfam07354
    Location:55 → 326
    Sp38; Zona-pellucida-binding protein (Sp38)

  4. NM_199419.3 → NP_955451.2  zona pellucida-binding protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_955451.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL591125, BC089476
    Consensus CDS
    CCDS25354.1
    UniProtKB/TrEMBL
    Q5FWC7
    Related
    ENSMUSP00000079822.7, ENSMUST00000081033.13
    Conserved Domains (1) summary
    pfam07354
    Location:55 → 253
    Sp38; Zona-pellucida-binding protein (Sp38)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98441923..98449491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6X786.2 GenPept UniProtKB/Swiss-Prot:Q6X786

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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