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MIR619 microRNA 619 [ Homo sapiens (human) ]

Gene ID: 693204, updated on 20-Nov-2023

Summary

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Official Symbol
MIR619provided by HGNC
Official Full Name
microRNA 619provided by HGNC
Primary source
HGNC:HGNC:32875
See related
Ensembl:ENSG00000207622 miRBase:MI0003633; AllianceGenome:HGNC:32875
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN619; hsa-mir-619
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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See MIR619 in Genome Data Viewer
Location:
12q24.11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108836908..108837006, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108811606..108811704, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109230684..109230782, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:109185940-109186440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109187809-109188319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:109192141-109192642 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:109195372-109196325 Neighboring gene uncharacterized LOC101929204 Neighboring gene slingshot protein phosphatase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:109199370-109200569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:109207967-109208570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109221436-109222007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6980 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:109231638-109232837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109232831-109233432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4836 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:109247741-109248940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109250055-109250556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109273628-109274245 Neighboring gene MPRA-validated peak1937 silencer Neighboring gene uncharacterized LOC124903011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:109300977-109301477 Neighboring gene D-amino acid oxidase Neighboring gene NANOG hESC enhancer GRCh37_chr12:109311835-109312350 Neighboring gene SV2 related protein Neighboring gene RNA, U6 small nuclear 361, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4. Kim DH, et al. Cancer Lett, 2020 Apr 10. PMID 32004570
  2. The properties of binding sites of miR-619-5p, miR-5095, miR-5096, and miR-5585-3p in the mRNAs of human genes. Ivashchenko A, et al. Biomed Res Int, 2014. PMID 25162022, Free PMC Article
  3. Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression. Ma W, et al. Biochem Genet, 2022 Aug. PMID 35034245
  4. LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway. Mu M, et al. Oncogene, 2020 Nov. PMID 32978519, Free PMC Article
  5. Long noncoding RNA SBF2-AS1 promotes colorectal cancer proliferation and invasion by inhibiting miR-619-5p activity and facilitating HDAC3 expression. Chen G, et al. J Cell Physiol, 2019 Aug. PMID 30912164

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis.
    Title: hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis.
  2. Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression.
    Title: Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression.
  3. LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/beta-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
    Title: LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
  4. Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4.
    Title: Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4.
  5. LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway.
    Title: LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway.
  6. downregulation of miR-619-5p or HDAC3 overexpression reversed SBF2-AS1-silencing-caused suppression on proliferation and metastasis.
    Title: Long noncoding RNA SBF2-AS1 promotes colorectal cancer proliferation and invasion by inhibiting miR-619-5p activity and facilitating HDAC3 expression.
  7. In prostatic cancer, there is a significant increase in plasma hsa-miR-619-5p and hsa-miR-1184 microRNA expression.
    Title: Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer.
  8. Groups of mRNAs in which the ordering of the miR-619-5p, miR-5095, miR-5096, and miR-5585-3p binding sites differ were established
    Title: The properties of binding sites of miR-619-5p, miR-5095, miR-5096, and miR-5585-3p in the mRNAs of human genes.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • miR-619-5p

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_030350.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC087893
    Related
    ENST00000384890.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    108836908..108837006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    108811606..108811704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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