MIR601 microRNA 601 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR601provided by HGNC
Official Full Name: microRNA 601provided by HGNC
Primary source: HGNC:HGNC:32857
See related: Ensembl:ENSG00000207991 miRBase:MI0003614; AllianceGenome:HGNC:32857
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN601; hsa-mir-601
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 9q33.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (123402525..123402603, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (135600265..135600343, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (126164804..126164882, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of miR-106b-5p, miR-601, and miR-760 Expression and Their Clinical Values in Non-Small Cell Lung Cancer (NSCLC) Patients' Serum.
Title: Identification of miR-106b-5p, miR-601, and miR-760 Expression and Their Clinical Values in Non-Small Cell Lung Cancer (NSCLC) Patients' Serum.
MiR-601 Promotes Cell Proliferation of Human Glioblastoma Cells by Suppressing TINP1 Expression.
Title: MiR-601 Promotes Cell Proliferation of Human Glioblastoma Cells by Suppressing TINP1 Expression.
Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1.
Title: Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1.
MiR-601 suppressed the proliferation, invasion and migration of esophagus carcinoma cells by down-regulating HDAC6 expression.
Title: MiR-601 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) by targeting HDAC6.
miR-601 activates Nrf2 signaling to protect retinal pigment epithelial cells from H2O2 by targeting Cul3
Title: Targeting cullin 3 by miR-601 activates Nrf2 signaling to protect retinal pigment epithelium cells from hydrogen peroxide.
The expression level of miR-601 is dramatically up-regulated in gastric cancer
Title: Increased expression of miR-601 is associated with poor prognosis and tumor progression of gastric cancer.
overexpression of SIRT1 could reverse the effect of miR-601 on pancreatic cancer cells; miR-601 suppresses pancreatic cancer cell proliferation and migration
Title: Identification of miR-601 as a novel regulator in the development of pancreatic cancer.
miR-601 inhibits growth and invasion of breast cancer cells by targeting PTP4A1.
Title: miR-601 is a prognostic marker and suppresses cell growth and invasion by targeting PTP4A1 in breast cancer.
Plasma miR-601 and miR-760 can potentially serve as promising non-invasive biomarkers for the early detection of colorectal cancer.
Title: Plasma miR-601 and miR-760 are novel biomarkers for the early detection of colorectal cancer.
effect of hsa-miR-601 on gene expression changes in human lung cancer cells A549: findings suggest that hsa-miR-601 could affect a variety of signaling pathways accompanying orchestrated gene expression changes
Title: Profiling of molecular pathways regulated by microRNA 601.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.