MIR592 microRNA 592 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR592provided by HGNC
Official Full Name: microRNA 592provided by HGNC
Primary source: HGNC:HGNC:32848
See related: Ensembl:ENSG00000207692 miRBase:MI0003604; AllianceGenome:HGNC:32848
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN592; mir-592; hsa-mir-592
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 7q31.33

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (127058088..127058184, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (128369839..128369935, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (126698142..126698238, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-592 serves as a novel tumor suppressor in Uveal melanoma: bioinformatics analysis and in vitro cell function verification.
Title: MicroRNA-592 serves as a novel tumor suppressor in Uveal melanoma: bioinformatics analysis and in vitro cell function verification.
MicroRNA-592 Inhibits the Growth of Ovarian Cancer Cells by Targeting ERBB3.
Title: MicroRNA-592 Inhibits the Growth of Ovarian Cancer Cells by Targeting ERBB3.
MiR-592 activates the mTOR kinase, ERK1/ERK2 kinase signaling and imparts neuronal differentiation signature characteristic of Group 4 medulloblastoma.
Title: MiR-592 activates the mTOR kinase, ERK1/ERK2 kinase signaling and imparts neuronal differentiation signature characteristic of Group 4 medulloblastoma.
The regulation of microRNA in each of cancer stage from two different ethnicities as potential biomarker for breast cancer.
Title: The regulation of microRNA in each of cancer stage from two different ethnicities as potential biomarker for breast cancer.
MicroRNA592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC.
Title: MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC.
LncRNA WTAPP1 promotes proliferation of laryngeal carcinoma cells through regulating microRNA-592.
Title: LncRNA WTAPP1 promotes proliferation of laryngeal carcinoma cells through regulating microRNA-592.
miR592 acts as an oncogene and promotes medullary thyroid cancer tumorigenesis by targeting cyclindependent kinase 8.
Title: miR‑592 acts as an oncogene and promotes medullary thyroid cancer tumorigenesis by targeting cyclin‑dependent kinase 8.
The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression.
Title: The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression.
findings suggest that miR-592 acted as a tumor suppressor by targeting ROCK1 and may serve as a potential biomarker in acute myeloid leukemia
Title: MiR-592 functions as a tumor suppressor in acute myeloid leukemia by targeting ROCK1 and predicts patients' prognosis.
The results indicated that the NEAT1/miR592/NOVA1 pathway may play regulatory roles in thyroid cancer malignancy in vitro and in vivo. Our findings may provide novel insight into the pathogenesis of thyroid cancer.
Title: MicroRNA-592 suppresses the malignant phenotypes of thyroid cancer by regulating lncRNA NEAT1 and downregulating NOVA1.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Markers

ECD09365 (e-PCR)
- UniSTS:290409

REN113388 (e-PCR)
- UniSTS:438183

REN113389 (e-PCR)
- UniSTS:438184

stSG613364 (e-PCR)
- UniSTS:451496

REN113390 (e-PCR)
- UniSTS:438185

REN113391 (e-PCR)
- UniSTS:438186

REN113392 (e-PCR)
- UniSTS:438187

REN113393 (e-PCR)
- UniSTS:438188

REN113394 (e-PCR)
- UniSTS:438189

REN113395 (e-PCR)
- UniSTS:438190

REN113396 (e-PCR)
- UniSTS:438191

REN113397 (e-PCR)
- UniSTS:438192

ECD12064 (e-PCR)
- UniSTS:293097

ECD23384 (e-PCR)
- UniSTS:304368

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.