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Ppp1r42 protein phosphatase 1, regulatory subunit 42 [ Mus musculus (house mouse) ]

Gene ID: 69312, updated on 5-Mar-2024

Summary

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Official Symbol
Ppp1r42provided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 42provided by MGI
Primary source
MGI:MGI:1921138
See related
Ensembl:ENSMUSG00000025916 AllianceGenome:MGI:1921138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TLRR; Lrrc67; 1700011J18Rik; 4930418G15Rik
Summary
Enables actin binding activity; dynein complex binding activity; and tubulin binding activity. Involved in regulation of phosphatase activity. Located in centrosome and manchette. Is expressed in 4th ventricle lateral recess and lateral ventricle choroid plexus. Orthologous to human PPP1R42 (protein phosphatase 1 regulatory subunit 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.4), liver E18 (RPKM 0.1) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
1 A2; 1 2.25 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (10038847..10083766, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (9968622..10013541, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4304 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene small nucleolar RNA host gene 6 Neighboring gene transcription factor 24 Neighboring gene STARR-seq mESC enhancer starr_00178 Neighboring gene STARR-seq mESC enhancer starr_00179 Neighboring gene predicted gene, 24674 Neighboring gene STARR-positive B cell enhancer ABC_E270 Neighboring gene COP9 signalosome subunit 5 Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_00181 Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 1 Neighboring gene STARR-seq mESC enhancer starr_00182

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PP1 forms an active complex with TLRR (lrrc67), a putative PP1 regulatory subunit, during the early stages of spermiogenesis in mice. Wang R, et al. PLoS One, 2011. PMID 21738792, Free PMC Article
  2. Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids. Wang R, et al. BMC Cell Biol, 2008 Jan 31. PMID 18237440, Free PMC Article
  3. TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis. Wang R, et al. Biol Cell, 2010 Jan 13. PMID 19886865, Free PMC Article
  4. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our finding that TLRR is associated with microtubules in cultured cells suggests that TLRR may play a common role in modulating the cytoskeleton in other cell types besides male germ cells.
    Title: TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis.
  2. Identification of a previously uncharacterized leucine-rich repeat protein that is expressed abundantly in the testis.[TLRR; NM_027033.1, NM_145692.1]
    Title: Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids.
  3. 4930418G15Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
    Title: Tissue expression patterns identify mouse cilia genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dynein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in manchette IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 42
Names
leucine rich repeat containing 67
testis leucine-rich repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145692.2 → NP_663730.1  protein phosphatase 1 regulatory subunit 42

    See identical proteins and their annotated locations for NP_663730.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AK076637, AV253491
    Consensus CDS
    CCDS14817.1
    UniProtKB/Swiss-Prot
    Q8R1Z4, Q9D5M1, Q9DAF9
    Related
    ENSMUSP00000027049.4, ENSMUST00000027049.10
    Conserved Domains (3) summary
    sd00033
    Location:31 → 51
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:72 → 106
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:50 → 106
    LRR_8; Leucine rich repeat

RNA

  1. NR_110971.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate 3' exons, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK015164, AK076637, AV253491
    Related
    ENSMUST00000130102.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    10038847..10083766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495566.3 → XP_006495629.1  protein phosphatase 1 regulatory subunit 42 isoform X2

    UniProtKB/TrEMBL
    E9PUJ7
    Related
    ENSMUSP00000115309.2, ENSMUST00000124874.8
    Conserved Domains (2) summary
    sd00031
    Location:30 → 51
    LRR_1; leucine-rich repeat [structural motif]
    NF033189
    Location:27 → 180
    internalin_A; class 1 internalin InlA

  2. XM_006495565.2 → XP_006495628.1  protein phosphatase 1 regulatory subunit 42 isoform X1

    UniProtKB/TrEMBL
    E9PUJ7
    Conserved Domains (2) summary
    sd00031
    Location:30 → 51
    LRR_1; leucine-rich repeat [structural motif]
    NF033189
    Location:27 → 180
    internalin_A; class 1 internalin InlA

RNA

  1. XR_003946510.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027033.4: Suppressed sequence

    Description
    NM_027033.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1Z4.1 GenPept UniProtKB/Swiss-Prot:Q8R1Z4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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