Slc16a13 solute carrier family 16 (monocarboxylic acid transporters), member 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc16a13provided by MGI
Official Full Name: solute carrier family 16 (monocarboxylic acid transporters), member 13provided by MGI
Primary source: MGI:MGI:1916559
See related: Ensembl:ENSMUSG00000044367 AllianceGenome:MGI:1916559
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700007D07Rik
Summary: Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in Golgi apparatus and cytosol. Predicted to be integral component of plasma membrane. Orthologous to human SLC16A13 (solute carrier family 16 member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 11.5), genital fat pad adult (RPKM 6.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70107615..70113638, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70216789..70222740, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance.
Title: Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance.
PPARalpha up-regulates the expression of Slc16a13 in small intestine.
Title: PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

Slc16a13 (e-PCR), detects polymorphism
- UniSTS:547000

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables monocarboxylic acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monocarboxylic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: monocarboxylate transporter 13

Names: MCT 13; solute carrier family 16 member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172371.3 → NP_758959.1 monocarboxylate transporter 13

See identical proteins and their annotated locations for NP_758959.1

Status: PROVISIONAL

Source sequence(s)

AL669869

Consensus CDS

CCDS24938.1

UniProtKB/Swiss-Prot

Q8CE94, Q8CEH6, Q8CF46

Related

ENSMUSP00000053218.3, ENSMUST00000060010.3

Conserved Domains (2) summary

cd06174
Location:14 → 392

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00890
Location:14 → 383

2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

70107615..70113638 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534113.5 → XP_006534176.1 monocarboxylate transporter 13 isoform X1

See identical proteins and their annotated locations for XP_006534176.1

Conserved Domains (1) summary

cd17423
Location:13 → 344

MFS_MCT11_13; Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters