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Dcps decapping enzyme, scavenger [ Mus musculus (house mouse) ]

Gene ID: 69305, updated on 11-Apr-2024

Summary

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Official Symbol
Dcpsprovided by MGI
Official Full Name
decapping enzyme, scavengerprovided by MGI
Primary source
MGI:MGI:1916555
See related
Ensembl:ENSMUSG00000032040 AllianceGenome:MGI:1916555
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCS-1; HINT-5; 1700001E16Rik
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity; identical protein binding activity; and m7G(5')pppN diphosphatase activity. Predicted to be involved in cellular response to menadione; mRNA metabolic process; and negative regulation of programmed cell death. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in P-body and nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human DCPS (decapping enzyme, scavenger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 26.3), liver E14 (RPKM 24.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 19.71 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35035710..35087283, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35124414..35175987, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Neighboring gene predicted gene, 51705 Neighboring gene STARR-seq mESC enhancer starr_23763 Neighboring gene RIKEN cDNA 4930581F22 gene Neighboring gene predicted gene, 57537 Neighboring gene predicted gene, 24262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:34983517-34983704 Neighboring gene STARR-positive B cell enhancer ABC_E6723 Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene signal recognition particle receptor alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution. Han GW, et al. Proteins, 2005 Sep 1. PMID 16001405
  2. The natural antisense transcript NATTD regulates the transcription of decapping scavenger (DcpS) enzyme. Mei ZZ, et al. Int J Biochem Cell Biol, 2019 May. PMID 30858142
  3. The DcpS inhibitor RG3039 improves motor function in SMA mice. Van Meerbeke JP, et al. Hum Mol Genet, 2013 Oct 15. PMID 23727836, Free PMC Article
  4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NATTD as a regulator of DcpS transcription through epigenetic mechanisms
    Title: The natural antisense transcript NATTD regulates the transcription of decapping scavenger (DcpS) enzyme.
  2. Amino acid sequence and xray crystallograpy structure given
    Title: Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA cis splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA methylguanosine-cap decapping ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
m7GpppX diphosphatase
Names
decapping scavenger enzyme
hint-related 7meGMP-directed hydrolase
histidine triad nucleotide-binding protein 5
histidine triad protein member 5
mRNA decapping enzyme
scavenger mRNA-decapping enzyme DcpS
NP_081306.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027030.2 → NP_081306.1  m7GpppX diphosphatase

    See identical proteins and their annotated locations for NP_081306.1

    Status: PROVISIONAL

    Source sequence(s)
    AK005584
    Consensus CDS
    CCDS22957.1
    UniProtKB/Swiss-Prot
    Q8C5I7, Q9DAR7
    Related
    ENSMUSP00000034539.6, ENSMUST00000034539.12
    Conserved Domains (3) summary
    COG5075
    Location:46 → 320
    COG5075; Uncharacterized conserved protein [Function unknown]
    pfam05652
    Location:44 → 145
    DcpS; Scavenger mRNA decapping enzyme (DcpS) N-terminal
    pfam11969
    Location:174 → 281
    DcpS_C; Scavenger mRNA decapping enzyme C-term binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35035710..35087283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAR7.1 GenPept UniProtKB/Swiss-Prot:Q9DAR7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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