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Tmigd3 transmembrane and immunoglobulin domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 69296, updated on 5-Mar-2024

Summary

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Official Symbol
Tmigd3provided by MGI
Official Full Name
transmembrane and immunoglobulin domain containing 3provided by MGI
Primary source
MGI:MGI:5604098
See related
Ensembl:ENSMUSG00000000562 Ensembl:ENSMUSG00000074344 AllianceGenome:MGI:5604098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700001d09rik; 4930578J19Rik; Tg(H2-K-CALR*)del52Shmd
Summary
This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 3' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:11542). [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward testis adult (RPKM 42.0) See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105778174..105831360)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105870858..105924044)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RAS-related protein 1a Neighboring gene STARR-positive B cell enhancer ABC_E10203 Neighboring gene STARR-positive B cell enhancer ABC_E11208 Neighboring gene STARR-seq mESC enhancer starr_08637 Neighboring gene predicted gene 5547 Neighboring gene STARR-seq mESC enhancer starr_08638 Neighboring gene STARR-seq mESC enhancer starr_08639 Neighboring gene STARR-positive B cell enhancer ABC_E9566 Neighboring gene STARR-positive B cell enhancer ABC_E9567 Neighboring gene RIKEN cDNA I830077J02 gene Neighboring gene adenosine A3 receptor Neighboring gene STARR-seq mESC enhancer starr_08641 Neighboring gene ATP synthase peripheral stalk-membrane subunit b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms in mice. Shide K, et al. Blood, 2020 Jul 2. PMID 32219445, Free PMC Article
  2. Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib. Shide K, et al. Leukemia, 2017 May. PMID 27807369, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane domain-containing protein TMIGD3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174169.2 → NP_001167640.1  transmembrane domain-containing protein TMIGD3 isoform 3

    See identical proteins and their annotated locations for NP_001167640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes the same 5' terminal exon but lacks the remaining exons and instead includes an alternate 3' terminal exon, compared to variant 2. The 3' terminal exon is shared with that of the adenosine A3 receptor gene. The encoded isoform (3), which is shorter and distinct compared to isoform 2, represents the C-terminal region of the adenosine A3 receptor.
    Source sequence(s)
    AC121847, BC100416
    Consensus CDS
    CCDS51036.1
    UniProtKB/TrEMBL
    Q497R5
    Related
    ENSMUSP00000126710.2, ENSMUST00000164730.2
    Conserved Domains (1) summary
    pfam00001
    Location:1 → 137
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_027025.4 → NP_081301.2  transmembrane domain-containing protein TMIGD3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_081301.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2), which is a transmembrane and immunoglobulin domain-containing protein and it does not share any similarity with the adenosine A3 receptor.
    Source sequence(s)
    AC121847, AK005581, BC038878
    Consensus CDS
    CCDS38582.1
    UniProtKB/Swiss-Prot
    G3X8R9, Q9DAR9
    UniProtKB/TrEMBL
    A0A0G2JE84
    Related
    ENSMUSP00000010279.5, ENSMUST00000010279.10
    Conserved Domains (1) summary
    cl11960
    Location:24 → 105
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    105778174..105831360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3X8R9.1 GenPept UniProtKB/Swiss-Prot:G3X8R9

Gene LinkOut

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