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Rhobtb1 Rho-related BTB domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 69288, updated on 11-Apr-2024

Summary

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Official Symbol
Rhobtb1provided by MGI
Official Full Name
Rho-related BTB domain containing 1provided by MGI
Primary source
MGI:MGI:1916538
See related
Ensembl:ENSMUSG00000019944 AllianceGenome:MGI:1916538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700008H16Rik; 3110048G13Rik
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and regulation of cell shape. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Is expressed in several structures, including genitourinary system; heart; liver; lung; and stomach. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 5.9), ovary adult (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B5.3; 10 36.04 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (68987106..69127621)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (69151058..69291791)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24172 Neighboring gene predicted gene, 33263 Neighboring gene STARR-positive B cell enhancer ABC_E8862 Neighboring gene RIKEN cDNA A930033H14 gene Neighboring gene predicted gene, 40685 Neighboring gene ribosomal protein L30, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity. Mukohda M, et al. J Clin Invest, 2019 Mar 21. PMID 30896450, Free PMC Article
  2. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Ramos S, et al. Gene, 2002 Oct 2. PMID 12426103
  3. Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Lutz J, et al. Histochem Cell Biol, 2014 Nov. PMID 24923387
  4. MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Schenková K, et al. J Mol Biol, 2012 Oct 5. PMID 22709582
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RhoBTB1 protected from hypertension, vascular smooth muscle dysfunction, and arterial stiffness in at least two models of hypertension.
    Title: RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107538

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho-related BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081347.1 → NP_001074816.1  rho-related BTB domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001074816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC117209
    Consensus CDS
    CCDS35930.1
    UniProtKB/Swiss-Prot
    B2RPX3, Q9DAK3
    UniProtKB/TrEMBL
    Q499C9
    Related
    ENSMUSP00000020101.6, ENSMUST00000020101.12
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. NM_001252636.1 → NP_001239565.1  rho-related BTB domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001239565.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC117209, AK005770
    Consensus CDS
    CCDS35930.1
    UniProtKB/Swiss-Prot
    B2RPX3, Q9DAK3
    UniProtKB/TrEMBL
    Q499C9
    Related
    ENSMUSP00000132068.2, ENSMUST00000164034.8
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  3. NM_001252637.1 → NP_001239566.1  rho-related BTB domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001239566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC117209, BB611014, BC137646
    Consensus CDS
    CCDS35930.1
    UniProtKB/Swiss-Prot
    B2RPX3, Q9DAK3
    UniProtKB/TrEMBL
    Q499C9
    Related
    ENSMUSP00000065095.8, ENSMUST00000067908.14
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  4. NM_001252638.1 → NP_001239567.1  rho-related BTB domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001239567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC117209, BC144800
    UniProtKB/TrEMBL
    B7ZMU4, Q6A003
    Conserved Domains (3) summary
    cd18530
    Location:472 → 571
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:344 → 469
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    68987106..69127621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514049.5 → XP_006514112.1  rho-related BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006514112.1

    UniProtKB/Swiss-Prot
    B2RPX3, Q9DAK3
    UniProtKB/TrEMBL
    Q499C9
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. XM_006514048.5 → XP_006514111.1  rho-related BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006514111.1

    UniProtKB/Swiss-Prot
    B2RPX3, Q9DAK3
    UniProtKB/TrEMBL
    Q499C9
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  3. XM_036155982.1 → XP_036011875.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RPX3, Q9DAK3
    UniProtKB/TrEMBL
    Q499C9
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  4. XM_006514051.5 → XP_006514114.1  rho-related BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006514114.1

    UniProtKB/Swiss-Prot
    B2RPX3, Q9DAK3
    UniProtKB/TrEMBL
    Q499C9
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  5. XM_006514054.2 → XP_006514117.1  rho-related BTB domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006514117.1

    UniProtKB/TrEMBL
    B7ZMU4, Q6A003
    Conserved Domains (3) summary
    cd18530
    Location:472 → 571
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:344 → 469
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_006514052.5 → XP_006514115.1  rho-related BTB domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006514115.1

    UniProtKB/TrEMBL
    B7ZMU4, Q6A003
    Conserved Domains (3) summary
    cd18530
    Location:472 → 571
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:344 → 469
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  7. XM_006514053.5 → XP_006514116.1  rho-related BTB domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006514116.1

    UniProtKB/TrEMBL
    B7ZMU4, Q6A003
    Conserved Domains (3) summary
    cd18530
    Location:472 → 571
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:344 → 469
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  8. XM_036155983.1 → XP_036011876.1  rho-related BTB domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    Q6A003
    Conserved Domains (3) summary
    cd18530
    Location:443 → 542
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:315 → 440
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:10 → 58
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAK3.2 GenPept UniProtKB/Swiss-Prot:Q9DAK3

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