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Ctdspl CTD small phosphatase like [ Mus musculus (house mouse) ]

Gene ID: 69274, updated on 11-Apr-2024

Summary

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Official Symbol
Ctdsplprovided by MGI
Official Full Name
CTD small phosphatase likeprovided by MGI
Primary source
MGI:MGI:1916524
See related
Ensembl:ENSMUSG00000047409 AllianceGenome:MGI:1916524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCP3; HYA22; 2810418J22Rik
Summary
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; eye; nervous system; and reproductive system. Orthologous to human CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 32.1), subcutaneous fat pad adult (RPKM 20.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ctdspl in Genome Data Viewer
Location:
9 F3; 9 71.07 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118751313..118873187)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118926536..119044119)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene integrin alpha 9 Neighboring gene uncharacterized LOC102636563 Neighboring gene predicted gene, 51695 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118834312-118834499 Neighboring gene VISTA enhancer mm1627 Neighboring gene STARR-seq mESC enhancer starr_25464 Neighboring gene predicted gene, 53514 Neighboring gene predicted gene, 33645 Neighboring gene microRNA 26a-1 Neighboring gene villin-like Neighboring gene predicted gene, 51697 Neighboring gene phospholipase C, delta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Implication of nanos2-3'UTR in the expression and function of nanos2. Tsuda M, et al. Mech Dev, 2006 Jun. PMID 16806845
  2. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Zhu Y, et al. Nucleic Acids Res, 2012 May. PMID 22210897, Free PMC Article
  3. Maternal microRNAs are essential for mouse zygotic development. Tang F, et al. Genes Dev, 2007 Mar 15. PMID 17369397, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CTD small phosphatase-like protein
Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTDSP-like
NIF-like protein
NLI-interacting factor 1
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
nuclear LIM interactor-interacting factor 1
small C-terminal domain phosphatase 3
small CTD phosphatase 3
NP_598471.3
XP_006512325.1
XP_006512326.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133710.3 → NP_598471.3  CTD small phosphatase-like protein

    See identical proteins and their annotated locations for NP_598471.3

    Status: VALIDATED

    Source sequence(s)
    AA239542, AC055818, AC156800, AK013115
    Consensus CDS
    CCDS23605.1
    UniProtKB/Swiss-Prot
    P58465, Q52KL5
    Related
    ENSMUSP00000072852.6, ENSMUST00000073109.12
    Conserved Domains (2) summary
    COG5190
    Location:95 → 270
    FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]
    TIGR02251
    Location:106 → 265
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    118751313..118873187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512263.2 → XP_006512326.1  CTD small phosphatase-like protein isoform X2

    See identical proteins and their annotated locations for XP_006512326.1

    Conserved Domains (1) summary
    cl21460
    Location:1 → 108
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. XM_006512262.4 → XP_006512325.1  CTD small phosphatase-like protein isoform X1

    UniProtKB/TrEMBL
    G3UXN0
    Related
    ENSMUSP00000133755.2, ENSMUST00000172464.2
    Conserved Domains (1) summary
    TIGR02251
    Location:95 → 254
    HIF-SF_euk; Dullard-like phosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58465.3 GenPept UniProtKB/Swiss-Prot:P58465

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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