U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gins1 GINS complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 69270, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gins1provided by MGI
Official Full Name
GINS complex subunit 1provided by MGI
Primary source
MGI:MGI:1916520
See related
Ensembl:ENSMUSG00000027454 AllianceGenome:MGI:1916520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSF1; Gins4; mKIAA0186; 2810418N01Rik
Summary
Acts upstream of or within DNA replication and inner cell mass cell proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 55. Orthologous to human GINS1 (GINS complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 13.6), liver E14 (RPKM 13.1) and 11 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2 G3; 2 74.75 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150751482..150773200)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150909556..150931280)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 12 Neighboring gene predicted gene, 23598 Neighboring gene predicted gene, 54124 Neighboring gene STARR-positive B cell enhancer ABC_E11167 Neighboring gene STARR-seq mESC enhancer starr_06018 Neighboring gene STARR-seq mESC enhancer starr_06019 Neighboring gene ribosomal protein L41 pseudogene Neighboring gene eukaryotic translation initiation factor 4E-binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06020 Neighboring gene ninein-like Neighboring gene STARR-seq mESC enhancer starr_06023 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties. Nagahama Y, et al. Cancer Res, 2010 Feb 1. PMID 20103637
  2. Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration. Ueno M, et al. Blood, 2009 Jan 15. PMID 18984863
  3. PSF1 is essential for early embryogenesis in mice. Ueno M, et al. Mol Cell Biol, 2005 Dec. PMID 16287864, Free PMC Article
  4. Identification and characterization of mouse PSF1-binding protein, SLD5. Kong L, et al. Biochem Biophys Res Commun, 2006 Jan 27. PMID 16338220
  5. A key role for the GINS complex at DNA replication forks. Labib K, et al. Trends Cell Biol, 2007 Jun. PMID 17467990

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target.
    Title: PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.
  2. expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1
    Title: A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA strand elongation involved in mitotic DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA unwinding involved in DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within inner cell mass cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
  
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GINS complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
DNA replication complex GINS protein PSF1
Names
GINS complex subunit 1 (Psf1 homolog)
GINS complex subunit 4 (Sld5 homolog)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163476.1 → NP_001156948.1  DNA replication complex GINS protein PSF1 isoform 2

    See identical proteins and their annotated locations for NP_001156948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC027537, BQ553304
    UniProtKB/TrEMBL
    Q8K1A2
    Related
    ENSMUST00000140950.8
    Conserved Domains (1) summary
    cd11710
    Location:3 → 130
    GINS_A_psf1; Alpha-helical domain of GINS complex protein Psf1

  2. NM_027014.1 → NP_081290.1  DNA replication complex GINS protein PSF1 isoform 1

    See identical proteins and their annotated locations for NP_081290.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK013116, AW122649, BQ553304
    Consensus CDS
    CCDS50743.1
    UniProtKB/Swiss-Prot
    Q9CZ15
    UniProtKB/TrEMBL
    Q6ZQH1
    Related
    ENSMUSP00000028948.5, ENSMUST00000028948.5
    Conserved Domains (2) summary
    cd11710
    Location:3 → 130
    GINS_A_psf1; Alpha-helical domain of GINS complex protein Psf1
    COG5230
    Location:1 → 191
    COG5230; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    150751482..150773200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500133.3 → XP_006500196.1  DNA replication complex GINS protein PSF1 isoform X1

    Conserved Domains (1) summary
    cd11710
    Location:3 → 130
    GINS_A_psf1; Alpha-helical domain of GINS complex protein Psf1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZ15.1 GenPept UniProtKB/Swiss-Prot:Q9CZ15

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous