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Gtpbp4 GTP binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 69237, updated on 5-Mar-2024

Summary

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Official Symbol
Gtpbp4provided by MGI
Official Full Name
GTP binding protein 4provided by MGI
Primary source
MGI:MGI:1916487
See related
Ensembl:ENSMUSG00000021149 AllianceGenome:MGI:1916487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NGB; Crfg; Nog1; Gtpbp3; 2610028C09Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 17.1), placenta adult (RPKM 10.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A1; 13 3.64 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (9016039..9046080, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (8972070..8996116, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22115 Neighboring gene predicted gene, 23923 Neighboring gene isopentenyl-diphosphate delta isomerase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2396 Neighboring gene predicted gene, 36264 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene La ribonucleoprotein 4B Neighboring gene STARR-seq mESC enhancer starr_33610

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Restricting conformational flexibility of the switch II region creates a dominant-inhibitory phenotype in Obg GTPase Nog1. Lapik YR, et al. Mol Cell Biol, 2007 Nov. PMID 17785438, Free PMC Article
  2. The heme environment of mouse neuroglobin. Evidence for the presence of two conformations of the heme pocket. Couture M, et al. J Biol Chem, 2001 Sep 28. PMID 11473111
  3. Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease. Laping NJ, et al. J Am Soc Nephrol, 2001 May. PMID 11316846
  4. A vertebrate globin expressed in the brain. Burmester T, et al. Nature, 2000 Sep 28. PMID 11029004
  5. Two orthogonal cleavages separate subunit RNAs in mouse ribosome biogenesis. Wang M, et al. Nucleic Acids Res, 2014. PMID 25190460, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3.
    Title: NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3.
  2. These results suggest that conformational changes in the switch II element of Nog1 have a critical importance for the dissociation of preribosome-bound factors during intranucleolar maturation.
    Title: Restricting conformational flexibility of the switch II region creates a dominant-inhibitory phenotype in Obg GTPase Nog1.
  3. Resonance Raman spectroscopy was used to determine the structure of the heme environment in Ngb from mice.
    Title: The heme environment of mouse neuroglobin. Evidence for the presence of two conformations of the heme pocket.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables preribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of collagen binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTP-binding protein 4
Names
GTP binding protein 3
GTP-binding protein NGB
Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)
chronic renal failure gene protein
chronic renal failure protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418602.1 → NP_001405531.1  GTP-binding protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124732, AC125484

  2. NM_001418603.1 → NP_001405532.1  GTP-binding protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124732, AC125484

  3. NM_001418604.1 → NP_001405533.1  GTP-binding protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124732, AC125484

  4. NM_001418605.1 → NP_001405534.1  GTP-binding protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC124732, AC125484

  5. NM_001418606.1 → NP_001405535.1  GTP-binding protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC124732, AC125484

  6. NM_001418607.1 → NP_001405536.1  GTP-binding protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC124732, AC125484

  7. NM_027000.5 → NP_081276.2  GTP-binding protein 4 isoform 1

    See identical proteins and their annotated locations for NP_081276.2

    Status: VALIDATED

    Source sequence(s)
    AC124732, AC125484
    Consensus CDS
    CCDS26236.1
    UniProtKB/Swiss-Prot
    Q99K16, Q99ME9, Q99P78, Q9CT02
    Related
    ENSMUSP00000152412.2, ENSMUST00000222098.2
    Conserved Domains (3) summary
    cd01897
    Location:169 → 340
    NOG; Nucleolar GTP-binding protein (NOG)
    COG1084
    Location:5 → 345
    Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]
    pfam08155
    Location:396 → 446
    NOGCT; NOGCT (NUC087) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    9016039..9046080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99ME9.3 GenPept UniProtKB/Swiss-Prot:Q99ME9

Gene LinkOut

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