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Selenot selenoprotein T [ Mus musculus (house mouse) ]

Gene ID: 69227, updated on 11-Apr-2024

Summary

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Official Symbol
Selenotprovided by MGI
Official Full Name
selenoprotein Tprovided by MGI
Primary source
MGI:MGI:1916477
See related
Ensembl:ENSMUSG00000075700 AllianceGenome:MGI:1916477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Selt; 2810407C02Rik; 5730408P04Rik
Summary
This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 8. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in kidney adult (RPKM 32.3), placenta adult (RPKM 31.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 D; 3 28.61 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (58484057..58500965)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (58576636..58593544)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11710 Neighboring gene TSC22 domain family, member 2 Neighboring gene STARR-seq mESC enhancer starr_07749 Neighboring gene STARR-positive B cell enhancer ABC_E1618 Neighboring gene STARR-positive B cell enhancer ABC_E516 Neighboring gene STARR-positive B cell enhancer ABC_E3433 Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene STARR-seq mESC enhancer starr_07753 Neighboring gene STARR-seq mESC enhancer starr_07754 Neighboring gene STARR-positive B cell enhancer ABC_E9549 Neighboring gene glutamate rich 6 Neighboring gene predicted gene, 46806 Neighboring gene spermine synthase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SELENOT Deficiency in the Mouse Brain Impacts Catecholaminergic Neuron Density: An Immunohistochemical, in situ Hybridization and 3D Light-Sheet Imaging Study. Godefroy D, et al. Neuroendocrinology, 2023. PMID 35066506
  2. Hepatic Proteomic Analysis of Selenoprotein T Knockout Mice by TMT: Implications for the Role of Selenoprotein T in Glucose and Lipid Metabolism. Li K, et al. Int J Mol Sci, 2021 Aug 7. PMID 34445217, Free PMC Article
  3. Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice. Castex MT, et al. Mol Neurobiol, 2016 Nov. PMID 26497036
  4. miR-431-5p regulates apoptosis of cardiomyocytes after acute myocardial infarction via targeting selenoprotein T. Geng H, et al. Physiol Res, 2022 Mar 25. PMID 35043644, Free PMC Article
  5. Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis. Huang J, et al. FASEB J, 2020 Sep. PMID 32686857

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SELENOT Deficiency in the Mouse Brain Impacts Catecholaminergic Neuron Density: An Immunohistochemical, in situ Hybridization and 3D Light-Sheet Imaging Study.
    Title: SELENOT Deficiency in the Mouse Brain Impacts Catecholaminergic Neuron Density: An Immunohistochemical, in situ Hybridization and 3D Light-Sheet Imaging Study.
  2. miR-431-5p regulates apoptosis of cardiomyocytes after acute myocardial infarction via targeting selenoprotein T.
    Title: miR-431-5p regulates apoptosis of cardiomyocytes after acute myocardial infarction via targeting selenoprotein T.
  3. Hepatic Proteomic Analysis of Selenoprotein T Knockout Mice by TMT: Implications for the Role of Selenoprotein T in Glucose and Lipid Metabolism.
    Title: Hepatic Proteomic Analysis of Selenoprotein T Knockout Mice by TMT: Implications for the Role of Selenoprotein T in Glucose and Lipid Metabolism.
  4. Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis.
    Title: Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis.
  5. Selenoprotein T is a novel oligosaccharyltransferase subunit that regulates unfolded protein response signaling and ASTH secretion.
    Title: Selenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion.
  6. SelT exerts a neuroprotective role which is essential during brain development, and that its loss impairs mice behavior.
    Title: Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice.
  7. The SelT play a crucial role in the protection of dopaminergic neurons against oxidative stress and cell death, providing insight into the molecular underpinnings of this stress in PD.
    Title: Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease.
  8. Data suggest SelT is expressed in pancreatic beta- and delta-cells; inactivation of SelT in beta-cells leads to glucose intolerance via impaired glucose homeostasis and PACAP (pituitary adenylate cyclase-activating polypeptide) insulinotropic effect.
    Title: The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human β-cells and its targeted inactivation impairs glucose tolerance.
  9. Data show that the loss of SelT elevates expression of another selenoprotein, selenoprotein W, suggesting that SepW1 may functionally compensate for SelT.
    Title: Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular oxidant detoxification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thioredoxin reductase-like selenoprotein T
Names
thioredoxin reductase-like enzyme
NP_001035486.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040396.3 → NP_001035486.2  thioredoxin reductase-like selenoprotein T precursor

    See identical proteins and their annotated locations for NP_001035486.2

    Status: REVIEWED

    Source sequence(s)
    AA155383, AK013022, AK047958, BF660234, BY123391
    Consensus CDS
    CCDS38437.1
    UniProtKB/Swiss-Prot
    A2RTC6, P62342, Q8CHV4
    Related
    ENSMUSP00000103557.3, ENSMUST00000107924.3
    Conserved Domains (1) summary
    TIGR02174
    Location:41 → 179
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    58484057..58500965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026997.1: Suppressed sequence

    Description
    NM_026997.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62342.2 GenPept UniProtKB/Swiss-Prot:P62342

Gene LinkOut

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