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Snx24 sorting nexing 24 [ Mus musculus (house mouse) ]

Gene ID: 69226, updated on 5-Mar-2024

Summary

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Official Symbol
Snx24provided by MGI
Official Full Name
sorting nexing 24provided by MGI
Primary source
MGI:MGI:1916476
See related
Ensembl:ENSMUSG00000024535 AllianceGenome:MGI:1916476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810011K15Rik; 5730433I16Rik
Summary
Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in cytoplasmic vesicle and membrane. Orthologous to human SNX24 (sorting nexin 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 2.5), limb E14.5 (RPKM 1.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Snx24 in Genome Data Viewer
Location:
18 D1; 18 29.0 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (53376877..53523994)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (53243933..53390922)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4250 Neighboring gene sorting nexin 2 Neighboring gene Rac GTPase-activating protein 1 pseudogene Neighboring gene predicted gene, 54042 Neighboring gene predicted gene, 57647 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44622 Neighboring gene peptidylprolyl isomerase C Neighboring gene STARR-seq mESC enhancer starr_44623 Neighboring gene predicted gene, 41726

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells. Mizutani R, et al. Cell Signal, 2009 Nov. PMID 19576982
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370761.1 → NP_001357690.1  sorting nexin-24

    Status: VALIDATED

    Source sequence(s)
    AC109291, AC148020
    Consensus CDS
    CCDS29251.1
    UniProtKB/Swiss-Prot
    Q9CRB0
    Related
    ENSMUSP00000025417.9, ENSMUST00000025417.9
    Conserved Domains (1) summary
    cd06880
    Location:1 → 111
    PX_SNX22; The phosphoinositide binding Phox Homology domain of Sorting Nexin 22

  2. NM_029394.4 → NP_083670.1  sorting nexin-24

    See identical proteins and their annotated locations for NP_083670.1

    Status: VALIDATED

    Source sequence(s)
    AC109291, AC148020
    Consensus CDS
    CCDS29251.1
    UniProtKB/Swiss-Prot
    Q9CRB0
    Related
    ENSMUSP00000131423.2, ENSMUST00000165032.9
    Conserved Domains (1) summary
    cd06880
    Location:1 → 111
    PX_SNX22; The phosphoinositide binding Phox Homology domain of Sorting Nexin 22

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    53376877..53523994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246995.4 → XP_011245297.1  sorting nexin-24 isoform X1

    Conserved Domains (1) summary
    cl02563
    Location:79 → 127
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. XM_036161271.1 → XP_036017164.1  sorting nexin-24 isoform X2

    Conserved Domains (1) summary
    cl02563
    Location:1 → 84
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RNA

  1. XR_004939886.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRB0.1 GenPept UniProtKB/Swiss-Prot:Q9CRB0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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