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Dtwd1 DTW domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 69185, updated on 5-Mar-2024

Summary

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Official Symbol
Dtwd1provided by MGI
Official Full Name
DTW domain containing 1provided by MGI
Primary source
MGI:MGI:1916435
See related
Ensembl:ENSMUSG00000023330 AllianceGenome:MGI:1916435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810033A06Rik
Summary
Predicted to enable tRNA-uridine aminocarboxypropyltransferase activity. Predicted to be involved in tRNA modification. Predicted to act upstream of or within tRNA processing. Predicted to be active in nucleus. Orthologous to human DTWD1 (DTW domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 7.2), liver E14.5 (RPKM 5.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 61.76 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125993981..126007197)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126152085..126165277)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene predicted gene, 26496 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125977713-125977822 Neighboring gene predicted gene, 54149 Neighboring gene STARR-seq mESC enhancer starr_05598 Neighboring gene STARR-seq mESC enhancer starr_05599 Neighboring gene STARR-seq mESC enhancer starr_05600 Neighboring gene STARR-positive B cell enhancer ABC_E2643 Neighboring gene STARR-seq mESC enhancer starr_05601 Neighboring gene STARR-seq mESC enhancer starr_05602 Neighboring gene STARR-seq mESC enhancer starr_05603 Neighboring gene STARR-positive B cell enhancer mm9_chr2:126188755-126189056 Neighboring gene ATPase, class I, type 8B, member 4 Neighboring gene Brca1 associated protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables tRNA-uridine aminocarboxypropyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-uridine aminocarboxypropyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA-uridine aminocarboxypropyltransferase 1
Names
DTW domain-containing protein 1
NP_001342512.1
NP_081257.1
XP_006500193.1
XP_006500194.1
XP_006500195.1
XP_036018427.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355583.1 → NP_001342512.1  tRNA-uridine aminocarboxypropyltransferase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL929175
    Consensus CDS
    CCDS16682.1
    UniProtKB/Swiss-Prot
    Q9D8U7
    Conserved Domains (1) summary
    pfam03942
    Location:66 → 285
    DTW; DTW domain

  2. NM_026981.2 → NP_081257.1  tRNA-uridine aminocarboxypropyltransferase 1

    See identical proteins and their annotated locations for NP_081257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK007678, BM899290, BY240339
    Consensus CDS
    CCDS16682.1
    UniProtKB/Swiss-Prot
    Q9D8U7
    Related
    ENSMUSP00000127662.2, ENSMUST00000170908.8
    Conserved Domains (1) summary
    pfam03942
    Location:66 → 285
    DTW; DTW domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    125993981..126007197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500132.5 → XP_006500195.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam03942
    Location:88 → 241
    DTW; DTW domain

  2. XM_036162534.1 → XP_036018427.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam03942
    Location:88 → 241
    DTW; DTW domain

  3. XM_006500130.3 → XP_006500193.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006500193.1

    UniProtKB/Swiss-Prot
    Q9D8U7
    Conserved Domains (1) summary
    pfam03942
    Location:66 → 285
    DTW; DTW domain

  4. XM_006500131.3 → XP_006500194.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006500194.1

    UniProtKB/Swiss-Prot
    Q9D8U7
    Conserved Domains (1) summary
    pfam03942
    Location:66 → 285
    DTW; DTW domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8U7.1 GenPept UniProtKB/Swiss-Prot:Q9D8U7

Gene LinkOut

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