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Dyrk2 dual-specificity tyrosine phosphorylation regulated kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 69181, updated on 5-Mar-2024

Summary

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Official Symbol
Dyrk2provided by MGI
Official Full Name
dual-specificity tyrosine phosphorylation regulated kinase 2provided by MGI
Primary source
MGI:MGI:1330301
See related
Ensembl:ENSMUSG00000028630 AllianceGenome:MGI:1330301
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810038L18Rik
Summary
Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; and protein phosphorylation. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Part of ribonucleoprotein complex. Is expressed in several structures, including brain; eye; gut gland; hemolymphoid system gland; and reproductive system. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.4), large intestine adult (RPKM 9.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dyrk2 in Genome Data Viewer
Location:
10 D2; 10 66.75 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (118691507..118725144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (118855602..118889245, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11759 Neighboring gene predicted gene 4065 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:118264286-118264469 Neighboring gene predicted gene, 40776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:118319649-118319861 Neighboring gene predicted gene, 40777 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 38403 Neighboring gene predicted gene, 33624 Neighboring gene STARR-seq mESC enhancer starr_28029 Neighboring gene STARR-seq mESC enhancer starr_28030 Neighboring gene STARR-seq mESC enhancer starr_28031

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dual-specificity tyrosine phosphorylation-regulated kinase 2 regulates osteoclast fusion in a cell heterotypic manner. Guterman-Ram G, et al. J Cell Physiol, 2018 Jan. PMID 28332708
  2. DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε. Weiss CS, et al. PLoS One, 2013. PMID 24023715, Free PMC Article
  3. A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells. Park CS, et al. Blood, 2019 Nov 28. PMID 31515251, Free PMC Article
  4. mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development. Geiger JN, et al. Blood, 2001 Feb 15. PMID 11159515
  5. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. Taira N, et al. J Clin Invest, 2012 Mar. PMID 22307329, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
    Title: The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
  2. results suggest that DYRK2 is a molecular checkpoint controlling p53- and c-Myc-mediated regulation of survival and self-renewal in CML cells with leukemic-initiating capacity that can be targeted with small molecules.
    Title: A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells.
  3. Dyrk2 regulates osteoclast fusion in a cell heterotypic manner.
    Title: Dual-specificity tyrosine phosphorylation-regulated kinase 2 regulates osteoclast fusion in a cell heterotypic manner.
  4. DYRK2 regulates tumor progression through modulation of c-Jun and c-Myc
    Title: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 2
Names
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
NP_001014412.1
XP_006514109.3
XP_011241854.1
XP_036011873.1
XP_036011874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014390.2 → NP_001014412.1  dual specificity tyrosine-phosphorylation-regulated kinase 2

    See identical proteins and their annotated locations for NP_001014412.1

    Status: PROVISIONAL

    Source sequence(s)
    AC154039
    Consensus CDS
    CCDS24201.1
    UniProtKB/Swiss-Prot
    Q5U4C9
    Related
    ENSMUSP00000004281.9, ENSMUST00000004281.10
    Conserved Domains (2) summary
    smart00220
    Location:220 → 533
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:154 → 533
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    118691507..118725144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243552.3 → XP_011241854.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_011241854.1

    Conserved Domains (1) summary
    cd14224
    Location:81 → 460
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  2. XM_036155980.1 → XP_036011873.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

    Conserved Domains (1) summary
    cd14224
    Location:81 → 460
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  3. XM_006514046.5 → XP_006514109.3  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1

    Conserved Domains (1) summary
    cd14224
    Location:220 → 599
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  4. XM_036155981.1 → XP_036011874.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

    Conserved Domains (1) summary
    cd14224
    Location:81 → 460
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U4C9.1 GenPept UniProtKB/Swiss-Prot:Q5U4C9

Gene LinkOut

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