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Stimate STIM activating enhancer [ Mus musculus (house mouse) ]

Gene ID: 69179, updated on 11-Apr-2024

Summary

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Official Symbol
Stimateprovided by MGI
Official Full Name
STIM activating enhancerprovided by MGI
Primary source
MGI:MGI:1921500
See related
Ensembl:ENSMUSG00000006526 AllianceGenome:MGI:1921500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem110; 1810038N08Rik; 2310014H19Rik
Summary
Predicted to enable calcium channel regulator activity. Predicted to be involved in activation of store-operated calcium channel activity and calcium-mediated signaling using intracellular calcium source. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cortical endoplasmic reticulum and membrane. Is expressed in lung; spleen; stomach; and testis. Orthologous to several human genes including STIMATE (STIM activating enhancer). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 15.9), ovary adult (RPKM 12.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stimate in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30547533..30599167)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30825575..30877210)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Scm-like with four mbt domains 1 Neighboring gene RIKEN cDNA 1700087M22 gene Neighboring gene transformer 2 beta homolog pseudogene Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter alpha-trypsin inhibitor, heavy chain 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility. Tremblay MG, et al. Cell Cycle, 2016 Sep. PMID 27399837, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-mediated signaling using intracellular calcium source IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cortical endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cortical endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
store-operated calcium entry regulator STIMATE
Names
STIM-activating enhancer encoded by TMEM110
transmembrane protein 110

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028839.4 → NP_083115.3  store-operated calcium entry regulator STIMATE

    See identical proteins and their annotated locations for NP_083115.3

    Status: VALIDATED

    Source sequence(s)
    AK009341, BE944885, CJ180452, CT025528
    Consensus CDS
    CCDS26899.1
    UniProtKB/Swiss-Prot
    Q3U2J0, Q3UF25, Q8C691, Q8R3U0, Q9D7D4, Q9D8S1
    Related
    ENSMUSP00000006701.6, ENSMUST00000006701.8
    Conserved Domains (1) summary
    pfam12400
    Location:100 → 219
    STIMATE; STIMATE family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30547533..30599167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247992.2 → XP_030103852.1  store-operated calcium entry regulator STIMATE isoform X1

    Conserved Domains (1) summary
    pfam12400
    Location:58 → 177
    STIMATE; STIMATE family

  2. XM_036158839.1 → XP_036014732.1  store-operated calcium entry regulator STIMATE isoform X2

    Conserved Domains (1) summary
    pfam12400
    Location:6 → 85
    STIMATE; STIMATE family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UF25.1 GenPept UniProtKB/Swiss-Prot:Q3UF25

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