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Lzic leucine zipper and CTNNBIP1 domain containing [ Mus musculus (house mouse) ]

Gene ID: 69151, updated on 5-Mar-2024

Summary

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Official Symbol
Lzicprovided by MGI
Official Full Name
leucine zipper and CTNNBIP1 domain containingprovided by MGI
Primary source
MGI:MGI:1916401
See related
Ensembl:ENSMUSG00000028990 AllianceGenome:MGI:1916401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810030J04Rik
Summary
Predicted to enable beta-catenin binding activity. Orthologous to human LZIC (leucine zipper and CTNNBIP1 domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 12.1), limb E14.5 (RPKM 10.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lzic in Genome Data Viewer
Location:
4 E2; 4 79.53 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149569642..149581952)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149485185..149503516)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 11-2, pseudogene 2 Neighboring gene retinol binding protein 7, cellular Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_12115 Neighboring gene transmembrame protein 274 Neighboring gene STARR-seq mESC enhancer starr_12116 Neighboring gene STARR-positive B cell enhancer mm9_chr4:148891953-148892254 Neighboring gene catenin beta interacting protein 1 Neighboring gene predicted gene, 24381 Neighboring gene microRNA 5616

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LZIC regulates neuronal survival during zebrafish development. Clements WK, et al. Dev Biol, 2005 Jul 15. PMID 15932753
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein LZIC
Names
leucine zipper and CTNNBIP1 domain-containing protein
leucine zipper and ICAT homologous domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356322.1 → NP_001343251.1  protein LZIC

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK146824, AW047580, BY146654, CN455726
    Consensus CDS
    CCDS18961.1
    UniProtKB/Swiss-Prot
    Q8K3C3, Q9D8V3
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 188
    ICAT; Beta-catenin-interacting protein ICAT

  2. NM_026963.6 → NP_081239.1  protein LZIC

    See identical proteins and their annotated locations for NP_081239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK146824, AW047580
    Consensus CDS
    CCDS18961.1
    UniProtKB/Swiss-Prot
    Q8K3C3, Q9D8V3
    Related
    ENSMUSP00000030842.8, ENSMUST00000030842.8
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 188
    ICAT; Beta-catenin-interacting protein ICAT

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149569642..149581952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253760.2 → XP_030109620.1  protein LZIC isoform X1

    Conserved Domains (1) summary
    pfam06384
    Location:139 → 214
    ICAT; Beta-catenin-interacting protein ICAT

  2. XM_030253762.2 → XP_030109622.1  protein LZIC isoform X2

    UniProtKB/Swiss-Prot
    Q8K3C3, Q9D8V3
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 188
    ICAT; Beta-catenin-interacting protein ICAT

  3. XM_036164403.1 → XP_036020296.1  protein LZIC isoform X2

    UniProtKB/Swiss-Prot
    Q8K3C3, Q9D8V3
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 188
    ICAT; Beta-catenin-interacting protein ICAT

  4. XM_030253763.2 → XP_030109623.1  protein LZIC isoform X2

    UniProtKB/Swiss-Prot
    Q8K3C3, Q9D8V3
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 188
    ICAT; Beta-catenin-interacting protein ICAT

  5. XM_017320382.3 → XP_017175871.1  protein LZIC isoform X2

    UniProtKB/Swiss-Prot
    Q8K3C3, Q9D8V3
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 188
    ICAT; Beta-catenin-interacting protein ICAT
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3C3.1 GenPept UniProtKB/Swiss-Prot:Q8K3C3

Gene LinkOut

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