U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kbtbd3 kelch repeat and BTB (POZ) domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 69149, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Kbtbd3provided by MGI
Official Full Name
kelch repeat and BTB (POZ) domain containing 3provided by MGI
Primary source
MGI:MGI:1916399
See related
Ensembl:ENSMUSG00000025893 AllianceGenome:MGI:1916399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bklhd3; 2200003A07Rik
Summary
Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and tooth. Orthologous to human KBTBD3 (kelch repeat and BTB domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 1.3), bladder adult (RPKM 1.3) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 2.46 cM; 9 A1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (4309743..4331829)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (4309743..4331829)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:4309539-4309751 Neighboring gene predicted gene, 53494 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene STARR-seq mESC enhancer starr_23158 Neighboring gene STARR-positive B cell enhancer ABC_E2280 Neighboring gene Myb/SANT-like DNA-binding domain containing 4 with coiled-coils Neighboring gene predicted gene, 53495 Neighboring gene glutamate receptor, ionotropic, AMPA4 (alpha 4) Neighboring gene STARR-seq mESC enhancer starr_23160 Neighboring gene predicted gene, 46101

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kelch repeat and BTB domain-containing protein 3
Names
BTB and kelch domain containing 3
BTB and kelch domain-containing protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164574.1 → NP_001158046.1  kelch repeat and BTB domain-containing protein 3

    See identical proteins and their annotated locations for NP_001158046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK078744, BB264869
    Consensus CDS
    CCDS22795.1
    UniProtKB/Swiss-Prot
    Q8BHI4, Q8BNJ8
    Related
    ENSMUSP00000050183.8, ENSMUST00000049648.9
    Conserved Domains (3) summary
    PHA03098
    Location:38 → 582
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 385
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:24 → 153
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

  2. NM_026962.3 → NP_081238.2  kelch repeat and BTB domain-containing protein 3

    See identical proteins and their annotated locations for NP_081238.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK078744, AK083497, BE650264
    Consensus CDS
    CCDS22795.1
    UniProtKB/Swiss-Prot
    Q8BHI4, Q8BNJ8
    Related
    ENSMUSP00000148445.2, ENSMUST00000212221.2
    Conserved Domains (3) summary
    PHA03098
    Location:38 → 582
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 385
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:24 → 153
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    4309743..4331829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242367.2 → XP_011240669.1  kelch repeat and BTB domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011240669.1

    UniProtKB/Swiss-Prot
    Q8BHI4, Q8BNJ8
    Conserved Domains (3) summary
    PHA03098
    Location:38 → 582
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 385
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:24 → 153
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

  2. XM_036155240.1 → XP_036011133.1  kelch repeat and BTB domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHI4, Q8BNJ8
    Conserved Domains (3) summary
    PHA03098
    Location:38 → 582
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 385
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:24 → 153
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

  3. XM_011242368.3 → XP_011240670.1  kelch repeat and BTB domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011240670.1

    UniProtKB/Swiss-Prot
    Q8BHI4, Q8BNJ8
    Conserved Domains (3) summary
    PHA03098
    Location:38 → 582
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 385
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:24 → 153
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

  4. XM_036155241.1 → XP_036011134.1  kelch repeat and BTB domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHI4, Q8BNJ8
    Conserved Domains (3) summary
    PHA03098
    Location:38 → 582
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 385
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:24 → 153
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

  5. XM_030244559.1 → XP_030100419.1  kelch repeat and BTB domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHI4, Q8BNJ8
    Conserved Domains (3) summary
    PHA03098
    Location:38 → 582
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 385
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:24 → 153
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHI4.1 GenPept UniProtKB/Swiss-Prot:Q8BHI4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous