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Gsdmd gasdermin D [ Mus musculus (house mouse) ]

Gene ID: 69146, updated on 11-Apr-2024

Summary

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Official Symbol
Gsdmdprovided by MGI
Official Full Name
gasdermin Dprovided by MGI
Primary source
MGI:MGI:1916396
See related
Ensembl:ENSMUSG00000022575 AllianceGenome:MGI:1916396
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DF5L; M2-4; Dfna5l; GsdmD-1; Gsdmdc1; 1810036L03Rik
Summary
Enables phospholipid binding activity and wide pore channel activity. Involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Acts upstream of or within cellular response to extracellular stimulus. Located in cytosol; extracellular space; and plasma membrane. Part of NLRP3 inflammasome complex. Is expressed in several structures, including gut; liver; lung; metanephros; and spleen. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 65.8), small intestine adult (RPKM 51.8) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Gsdmd in Genome Data Viewer
Location:
15 D3; 15 35.0 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75733990..75739257)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75862144..75867408)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39021 Neighboring gene predicted gene, 53897 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_39025 Neighboring gene maestro heat-like repeat family member 6 Neighboring gene nicotinate phosphoribosyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice. Traughber CA, et al. iScience, 2023 Feb 17. PMID 36844454, Free PMC Article
  2. NET formation is independent of gasdermin D and pyroptotic cell death. Stojkov D, et al. Sci Signal, 2023 Jan 24. PMID 36693132
  3. GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice. Sonny S, et al. Sci Rep, 2023 Jan 4. PMID 36599874, Free PMC Article
  4. Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis. Gao J, et al. Adv Sci (Weinh), 2023 Feb. PMID 36567267, Free PMC Article
  5. Gasdermin D protects against Streptococcus equi subsp. zooepidemicus infection through macrophage pyroptosis. Xu G, et al. Front Immunol, 2022. PMID 36311722, Free PMC Article

See all (203) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction.
    Title: Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction.
  2. Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis.
    Title: Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis.
  3. NLRP3-GSDMD-dependent IL-1beta Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model.
    Title: NLRP3-GSDMD-dependent IL-1β Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model.
  4. Macrophage-derived GSDMD promotes abdominal aortic aneurysm and aortic smooth muscle cells pyroptosis.
    Title: Macrophage-derived GSDMD promotes abdominal aortic aneurysm and aortic smooth muscle cells pyroptosis.
  5. Irisin improves diabetic cardiomyopathy-induced cardiac remodeling by regulating GSDMD-mediated pyroptosis through MITOL/STING signaling.
    Title: Irisin improves diabetic cardiomyopathy-induced cardiac remodeling by regulating GSDMD-mediated pyroptosis through MITOL/STING signaling.
  6. O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis.
    Title: O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis.
  7. CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma.
    Title: CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma.
  8. PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic Myocardial Injury.
    Title: PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic Myocardial Injury.
  9. Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection.
    Title: Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection.
  10. Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration.
    Title: Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration.
Submit: New GeneRIF Correction See all GeneRIFs (106)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cardiolipin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables wide pore channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in pore complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-1 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-18 production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyroptosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NLRP3 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NLRP3 inflammasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of canonical inflammasome complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gasdermin-D
Names
gasdermin domain containing 1
gasdermin domain-containing protein 1
gasderminD-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026960.4 → NP_081236.1  gasdermin-D

    See identical proteins and their annotated locations for NP_081236.1

    Status: PROVISIONAL

    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27551.1
    UniProtKB/Swiss-Prot
    Q3TBD9, Q9D8T2
    UniProtKB/TrEMBL
    A0A679AXP3
    Related
    ENSMUSP00000023238.5, ENSMUST00000023238.6
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 243
    Gasdermin; Gasdermin family
    pfam17708
    Location:287 → 459
    Gasdermin_C; Gasdermin PUB domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75733990..75739257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521343.5 → XP_006521406.1  gasdermin-D isoform X1

    Conserved Domains (2) summary
    pfam04598
    Location:18 → 123
    Gasdermin; Gasdermin family
    pfam17708
    Location:167 → 339
    Gasdermin_C; Gasdermin PUB domain

RNA

  1. XR_004938868.1 RNA Sequence

  2. XR_384037.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8T2.1 GenPept UniProtKB/Swiss-Prot:Q9D8T2

Gene LinkOut

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