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Cdk12 cyclin dependent kinase 12 [ Mus musculus (house mouse) ]

Gene ID: 69131, updated on 21-Apr-2024

Summary

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Official Symbol
Cdk12provided by MGI
Official Full Name
cyclin dependent kinase 12provided by MGI
Primary source
MGI:MGI:1098802
See related
Ensembl:ENSMUSG00000003119 AllianceGenome:MGI:1098802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crk7; Pksc; Crkrs; D11Ertd752e; 1810022J16Rik
Summary
Enables protein kinase binding activity. Acts upstream of or within negative regulation of stem cell differentiation. Predicted to be located in nuclear speck. Predicted to be part of cyclin K-CDK12 complex and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; early embryo; future brain; primitive streak; and unsegmented mesenchyme. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.5), limb E14.5 (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 61.75 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98093259..98171941)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98202433..98281101)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E10712 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr11:98063825-98064126 Neighboring gene predicted gene, 38963 Neighboring gene STARR-positive B cell enhancer ABC_E7054 Neighboring gene microRNA 5119 Neighboring gene STARR-seq mESC enhancer starr_30664 Neighboring gene predicted gene, 31194 Neighboring gene predicted gene, 31317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway. Liu S, et al. Exp Cell Res, 2023 Jul 1. PMID 37100369
  2. Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer. Cheng L, et al. Cancer Res, 2022 Oct 4. PMID 35857807
  3. Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene. Wang B, et al. Mol Ther, 2022 Oct 5. PMID 35581939, Free PMC Article
  4. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. Dubbury SJ, et al. Nature, 2018 Dec. PMID 30487607, Free PMC Article
  5. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. Chen HR, et al. Exp Neurol, 2014 Nov. PMID 24999027

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/beta-catenin signaling pathway.
    Title: Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.
  2. The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
    Title: The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
  3. Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
    Title: Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
  4. Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene.
    Title: Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene.
  5. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation; work clarifies the function of CDK12 and underscores its potential both as a chemotherapeutic target and as a tumour biomarker
    Title: CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
  6. Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos.
    Title: Cdk12 is essential for embryonic development and the maintenance of genomic stability.
  7. Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways
    Title: Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.
  8. The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
    Title: Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141525

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cyclin K-CDK12 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 12
Names
CDC2-related kinase 7
CDC2-related kinase, arginine/serine-rich
CDC2-related protein kinase 7
cell division cycle 2-related protein kinase 7
cell division protein kinase 12
protein kinase for splicing component
NP_001103096.1
NP_001103098.1
NP_081228.2
XP_006534171.1
XP_011247527.1
XP_030102133.1
XP_030102134.1
XP_030102135.1
XP_036012845.1
XP_036012846.1
XP_036012848.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109626.1 → NP_001103096.1  cyclin-dependent kinase 12 isoform 1

    See identical proteins and their annotated locations for NP_001103096.1

    Status: VALIDATED

    Source sequence(s)
    AA066711, AK049376, AL591205, BC116645
    Consensus CDS
    CCDS48901.1
    UniProtKB/Swiss-Prot
    A2A530, A2A531, B1AQH7, Q14AX6, Q6ZQ27, Q8R457
    Related
    ENSMUSP00000103162.2, ENSMUST00000107538.2
    Conserved Domains (1) summary
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  2. NM_001109628.1 → NP_001103098.1  cyclin-dependent kinase 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA066711, AK129237, AL591205, BC116645
    Consensus CDS
    CCDS48902.1
    UniProtKB/Swiss-Prot
    Q14AX6
    Related
    ENSMUSP00000103163.2, ENSMUST00000107539.8
    Conserved Domains (1) summary
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  3. NM_026952.2 → NP_081228.2  cyclin-dependent kinase 12 isoform 3

    See identical proteins and their annotated locations for NP_081228.2

    Status: VALIDATED

    Source sequence(s)
    AA066711, AL591205, BC116645
    Consensus CDS
    CCDS25342.1
    UniProtKB/Swiss-Prot
    Q14AX6
    Related
    ENSMUSP00000003203.8, ENSMUST00000003203.14
    Conserved Domains (2) summary
    smart00220
    Location:723 → 1016
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RNA

  1. NR_175406.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205

  2. NR_175407.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205

  3. NR_175408.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205

  4. NR_175409.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205

  5. NR_175478.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98093259..98171941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246273.1 → XP_030102133.1  cyclin-dependent kinase 12 isoform X1

    UniProtKB/Swiss-Prot
    A2A530, A2A531, B1AQH7, Q14AX6, Q6ZQ27, Q8R457
    Conserved Domains (1) summary
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  2. XM_006534108.4 → XP_006534171.1  cyclin-dependent kinase 12 isoform X2

    Conserved Domains (1) summary
    cd07864
    Location:714 → 1015
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  3. XM_036156952.1 → XP_036012845.1  cyclin-dependent kinase 12 isoform X4

    Conserved Domains (1) summary
    cd07864
    Location:714 → 1015
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  4. XM_011249225.4 → XP_011247527.1  cyclin-dependent kinase 12 isoform X10

    See identical proteins and their annotated locations for XP_011247527.1

    Conserved Domains (1) summary
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  5. XM_036156955.1 → XP_036012848.1  cyclin-dependent kinase 12 isoform X9

    Conserved Domains (2) summary
    PRK08691
    Location:1136 → 1313
    PRK08691; DNA polymerase III subunits gamma and tau; Validated
    cd07864
    Location:715 → 997
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  6. XM_030246274.2 → XP_030102134.1  cyclin-dependent kinase 12 isoform X1

    UniProtKB/Swiss-Prot
    A2A530, A2A531, B1AQH7, Q14AX6, Q6ZQ27, Q8R457
    Conserved Domains (1) summary
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  7. XM_030246275.2 → XP_030102135.1  cyclin-dependent kinase 12 isoform X3

    Conserved Domains (1) summary
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  8. XM_036156953.1 → XP_036012846.1  cyclin-dependent kinase 12 isoform X5

    Conserved Domains (1) summary
    cd07864
    Location:715 → 997
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14AX6.2 GenPept UniProtKB/Swiss-Prot:Q14AX6

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