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Cnot8 CCR4-NOT transcription complex, subunit 8 [ Mus musculus (house mouse) ]

Gene ID: 69125, updated on 18-Apr-2024

Summary

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Official Symbol
Cnot8provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 8provided by MGI
Primary source
MGI:MGI:1916375
See related
Ensembl:ENSMUSG00000020515 AllianceGenome:MGI:1916375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500015I04Rik; 1810022F04Rik
Summary
Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Predicted to act upstream of or within gene silencing by RNA and regulation of translation. Predicted to be located in nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human CNOT8 (CCR4-NOT transcription complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 34.1), CNS E14 (RPKM 23.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 35.69 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57983620..58009423)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58092794..58118597)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29589 Neighboring gene STARR-positive B cell enhancer ABC_E8407 Neighboring gene STARR-positive B cell enhancer ABC_E10676 Neighboring gene reduced expression 3 (Rex3) pseudogene Neighboring gene STARR-seq mESC enhancer starr_29598 Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene predicted gene, 51897 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E10677 Neighboring gene STARR-seq mESC enhancer starr_29600 Neighboring gene predicted gene 12247 Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E5229 Neighboring gene mitochondrial ribosomal protein L22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex. Stoney PN, et al. J Mol Biol, 2022 May 15. PMID 35248544
  2. The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs. Pasternak M, et al. Open Biol, 2016 Sep. PMID 27605379, Free PMC Article
  3. Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition. Quan Y, et al. Nucleic Acids Res, 2022 May 6. PMID 35390160, Free PMC Article
  4. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. Mostafa D, et al. RNA Biol, 2020 Mar. PMID 31924127, Free PMC Article
  5. Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development. Chen C, et al. Biochem Biophys Res Commun, 2011 Jul 29. PMID 21741365

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.
    Title: CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.
  2. Cnot8 eliminates naive regulation networks and is essential for naive-to-formative pluripotency transition.
    Title: Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition.
  3. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
    Title: Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
  4. study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
    Title: The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 8
Names
CCR4-associated factor 8
NP_001343406.1
NP_001350013.1
NP_001350014.1
NP_001350015.1
NP_081225.1
XP_006534165.1
XP_036012844.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356477.2 → NP_001343406.1  CCR4-NOT transcription complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AK007581, AK075727, AK150757, BY419531
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532, Q9D8X5
    Related
    ENSMUSP00000104471.2, ENSMUST00000108843.8
    Conserved Domains (1) summary
    cl23804
    Location:1 → 263
    CAF1; CAF1 family ribonuclease

  2. NM_001363084.1 → NP_001350013.1  CCR4-NOT transcription complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AL672182, BB843287
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532, Q9D8X5
    Conserved Domains (1) summary
    cl23804
    Location:1 → 263
    CAF1; CAF1 family ribonuclease

  3. NM_001363085.1 → NP_001350014.1  CCR4-NOT transcription complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AL672182
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532, Q9D8X5
    Conserved Domains (1) summary
    cl23804
    Location:1 → 263
    CAF1; CAF1 family ribonuclease

  4. NM_001363086.1 → NP_001350015.1  CCR4-NOT transcription complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AL672182
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532, Q9D8X5
    Conserved Domains (1) summary
    cl23804
    Location:1 → 263
    CAF1; CAF1 family ribonuclease

  5. NM_026949.5 → NP_081225.1  CCR4-NOT transcription complex subunit 8

    See identical proteins and their annotated locations for NP_081225.1

    Status: VALIDATED

    Source sequence(s)
    AK075727, AK150757, BY419531, CD553562
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532, Q9D8X5
    Related
    ENSMUSP00000020822.6, ENSMUST00000020822.12
    Conserved Domains (1) summary
    cl23804
    Location:1 → 263
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    57983620..58009423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534102.2 → XP_006534165.1  CCR4-NOT transcription complex subunit 8 isoform X1

    See identical proteins and their annotated locations for XP_006534165.1

    UniProtKB/Swiss-Prot
    Q3U532, Q9D8X5
    Conserved Domains (1) summary
    cl23804
    Location:1 → 263
    CAF1; CAF1 family ribonuclease

  2. XM_036156951.1 → XP_036012844.1  CCR4-NOT transcription complex subunit 8 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8X5.1 GenPept UniProtKB/Swiss-Prot:Q9D8X5

Gene LinkOut

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