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Eci3 enoyl-Coenzyme A delta isomerase 3 [ Mus musculus (house mouse) ]

Gene ID: 69123, updated on 3-Apr-2024

Summary

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Official Symbol
Eci3provided by MGI
Official Full Name
enoyl-Coenzyme A delta isomerase 3provided by MGI
Primary source
MGI:MGI:1916373
See related
Ensembl:ENSMUSG00000021416 AllianceGenome:MGI:1916373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kseg2; 1810022C23Rik
Summary
Enables dodecenoyl-CoA delta-isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in peroxisome. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 36.9), large intestine adult (RPKM 4.5) and 2 other tissues See more
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Genomic context

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Location:
13 A3.3; 13 14.23 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (35130595..35147971, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34946614..34963988, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34164 Neighboring gene family with sequence similarity 217, member A Neighboring gene testis expressed 56 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_34165 Neighboring gene predicted gene, 16984 Neighboring gene STARR-seq mESC enhancer starr_34167 Neighboring gene enoyl-Coenzyme A delta isomerase 2 Neighboring gene STARR-seq mESC enhancer starr_34168 Neighboring gene predicted gene, 46408 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:35127596-35127929 Neighboring gene STARR-seq mESC enhancer starr_34169 Neighboring gene predicted gene, 40910

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase. van Weeghel M, et al. FASEB J, 2014 Mar. PMID 24344334
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse Eci3 is almost exclusively expressed in kidney.
    Title: Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase.
  2. Eci3 specifically evolved in rodents after gene duplication of Eci2 and is localized to the peroxisomes
    Title: Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
enables intramolecular oxidoreductase activity, transposing C=C bonds ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid beta-oxidation IC
Inferred by Curator
more info
 PubMed 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
enoyl-CoA delta isomerase 3, peroxisomal
Names
D3,D2-enoyl-CoA isomerase
delta(3),delta(2)-enoyl-CoA isomerase
dodecenoyl-CoA isomerase
kidney specific expressed protein 2
NP_001405475.1
NP_001405476.1
NP_081223.1
XP_011242645.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418546.1 → NP_001405475.1  enoyl-CoA delta isomerase 3, peroxisomal isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124537
    UniProtKB/Swiss-Prot
    D3U0D8, Q78JN3
    Related
    ENSMUSP00000132701.2, ENSMUST00000164155.2

  2. NM_001418547.1 → NP_001405476.1  enoyl-CoA delta isomerase 3, peroxisomal isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124537

  3. NM_026947.5 → NP_081223.1  enoyl-CoA delta isomerase 3, peroxisomal isoform 1

    See identical proteins and their annotated locations for NP_081223.1

    Status: VALIDATED

    Source sequence(s)
    AC124537
    Consensus CDS
    CCDS26449.1
    UniProtKB/Swiss-Prot
    D3U0D8, Q78JN3
    UniProtKB/TrEMBL
    E9PY42
    Related
    ENSMUSP00000021853.6, ENSMUST00000021853.12
    Conserved Domains (2) summary
    cd06558
    Location:64 → 256
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    pfam00887
    Location:2 → 37
    ACBP; Acyl CoA binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    35130595..35147971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244343.3 → XP_011242645.1  enoyl-CoA delta isomerase 3, peroxisomal isoform X2

    UniProtKB/TrEMBL
    E9PY42
    Conserved Domains (2) summary
    cd06558
    Location:64 → 220
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    pfam00887
    Location:2 → 37
    ACBP; Acyl CoA binding protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78JN3.1 GenPept UniProtKB/Swiss-Prot:Q78JN3

Gene LinkOut

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