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Chrdl2 chordin-like 2 [ Mus musculus (house mouse) ]

Gene ID: 69121, updated on 18-Apr-2024

Summary

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Official Symbol
Chrdl2provided by MGI
Official Full Name
chordin-like 2provided by MGI
Primary source
MGI:MGI:1916371
See related
Ensembl:ENSMUSG00000030732 AllianceGenome:MGI:1916371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chl2; 1810022C01Rik
Summary
Acts upstream of or within cell differentiation and negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Is expressed in colon; genitourinary system; liver; and musculoskeletal system. Orthologous to human CHRDL2 (chordin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 4.3), placenta adult (RPKM 2.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E2; 7 54.29 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99655611..99683935)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100006404..100034728)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 169 Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19665 Neighboring gene SET translocation pseudogene Neighboring gene polymerase (DNA-directed), delta 3, accessory subunit Neighboring gene STARR-positive B cell enhancer ABC_E3737 Neighboring gene predicted gene, 34760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Oren A, et al. Gene, 2004 Apr 28. PMID 15094188
  2. Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation. Zakin L, et al. Dev Biol, 2008 Nov 1. PMID 18789316, Free PMC Article
  3. Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells. Souilhol C, et al. Nat Commun, 2016 Mar 8. PMID 26952187, Free PMC Article
  4. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Nakayama N, et al. Development, 2004 Jan. PMID 14660436
  5. BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. Forsman CL, et al. Dev Biol, 2013 Jan 1. PMID 23103586, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs.
    Title: A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chondrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chordin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291320.1 → NP_001278249.1  chordin-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001278249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC161205, AF338222, AK007577
    Consensus CDS
    CCDS80755.1
    UniProtKB/Swiss-Prot
    Q8VEA6, Q925I3
    UniProtKB/TrEMBL
    D3YV59
    Related
    ENSMUSP00000102699.2, ENSMUST00000107084.8
    Conserved Domains (1) summary
    cl17735
    Location:255 → 317
    VWC; von Willebrand factor type C domain

  2. NM_133709.3 → NP_598470.3  chordin-like protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_598470.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate first exon in place of that of variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC113298, AC161205, AF338222
    Consensus CDS
    CCDS21492.1
    UniProtKB/Swiss-Prot
    Q8VEA6, Q925I3
    UniProtKB/TrEMBL
    A0A0B4J1E8
    Related
    ENSMUSP00000032977.5, ENSMUST00000032977.11
    Conserved Domains (2) summary
    pfam00093
    Location:248 → 310
    VWC; von Willebrand factor type C domain
    cl17735
    Location:33 → 95
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99655611..99683935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508177.4 → XP_006508240.1  chordin-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VEA6, Q925I3
    Conserved Domains (1) summary
    pfam00093
    Location:163 → 225
    VWC; von Willebrand factor type C domain

  2. XM_006508178.1 → XP_006508241.1  chordin-like protein 2 isoform X2

    Conserved Domains (1) summary
    pfam00093
    Location:96 → 158
    VWC; von Willebrand factor type C domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEA6.1 GenPept UniProtKB/Swiss-Prot:Q8VEA6

Gene LinkOut

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