Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alkbh3provided by MGI
Official Full Name: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenaseprovided by MGI
Primary source: MGI:MGI:1916363
See related: Ensembl:ENSMUSG00000040174 AllianceGenome:MGI:1916363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abh3; mABH3; 1700108H04Rik; 1810020C19Rik
Summary: Enables 2-oxoglutarate-dependent dioxygenase activity and cytosine C-5 DNA demethylase activity. Predicted to be involved in DNA dealkylation; cell population proliferation; and oxidative single-stranded RNA demethylation. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 12.8), bladder adult (RPKM 7.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 51.62 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (93810979..93841099, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (93980624..94010824, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results revealed that N3-ethylthymidine , but not other DNA lesions, could be repaired by Alkbh2 and Alkbh3 in mammalian cells.
Title: Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions.
ALKBH2 and ALKBH3 provide cancer protection similar to that of the DNA glycosylase AAG and display apparent epistasis with Aag
Title: DNA repair is indispensable for survival after acute inflammation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-oxoglutarate-dependent dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables broad specificity oxidative DNA demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables broad specificity oxidative DNA demethylase activity	ISO Inferred from Sequence Orthology more info
enables cytosine C-5 DNA demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
NOT enables endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables mRNA N1-methyladenosine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidative RNA demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidative RNA demethylase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA alkylation repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Names: alkB, alkylation repair homolog 3; alkylated DNA repair protein alkB homolog 3

NP_001405608.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405609.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405611.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405613.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405614.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405616.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405618.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405619.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405621.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405623.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405625.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405627.1

EC 1.14.11.33

EC 1.14.11.54

NP_001405628.1

EC 1.14.11.33

EC 1.14.11.54

NP_081220.1

EC 1.14.11.33

EC 1.14.11.54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418679.1 → NP_001405608.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform a

Status: VALIDATED

Source sequence(s)

AL772372

UniProtKB/Swiss-Prot

Q8K1E6
NM_001418680.1 → NP_001405609.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform a

Status: VALIDATED

Source sequence(s)

AL772372

UniProtKB/Swiss-Prot

Q8K1E6
NM_001418682.1 → NP_001405611.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform a

Status: VALIDATED

Source sequence(s)

AL772372

UniProtKB/Swiss-Prot

Q8K1E6
NM_001418684.1 → NP_001405613.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform a

Status: VALIDATED

Source sequence(s)

AL772372

UniProtKB/Swiss-Prot

Q8K1E6
NM_001418685.1 → NP_001405614.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform a

Status: VALIDATED

Source sequence(s)

AL772372

UniProtKB/Swiss-Prot

Q8K1E6
NM_001418687.1 → NP_001405616.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform b

Status: VALIDATED

Source sequence(s)

AL772372
NM_001418689.1 → NP_001405618.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform b

Status: VALIDATED

Source sequence(s)

AL772372
NM_001418690.1 → NP_001405619.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform c

Status: VALIDATED

Source sequence(s)

AL772372
NM_001418692.1 → NP_001405621.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform c

Status: VALIDATED

Source sequence(s)

AL772372
NM_001418694.1 → NP_001405623.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform d

Status: VALIDATED

Source sequence(s)

AL772372
NM_001418696.1 → NP_001405625.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform e

Status: VALIDATED

Source sequence(s)

AL772372

Related

ENSMUSP00000122043.2, ENSMUST00000126378.8
NM_001418698.1 → NP_001405627.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform f

Status: VALIDATED

Source sequence(s)

AL772372
NM_001418699.1 → NP_001405628.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform f

Status: VALIDATED

Source sequence(s)

AL772372
NM_026944.2 → NP_081220.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform a

See identical proteins and their annotated locations for NP_081220.1

Status: VALIDATED

Source sequence(s)

AL772372

Consensus CDS

CCDS38184.1

UniProtKB/Swiss-Prot

Q8K1E6

UniProtKB/TrEMBL

A2AKV6

Related

ENSMUSP00000038721.7, ENSMUST00000040005.13

Conserved Domains (1) summary

cl21496
Location:90 → 275

2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily