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Stoml1 stomatin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 69106, updated on 5-Mar-2024

Summary

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Official Symbol
Stoml1provided by MGI
Official Full Name
stomatin-like 1provided by MGI
Primary source
MGI:MGI:1916356
See related
Ensembl:ENSMUSG00000032333 AllianceGenome:MGI:1916356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SLP1; STORP; UNC24; WPB72; 1810015E19Rik
Summary
Enables ion channel inhibitor activity. Acts upstream of or within SMAD protein signal transduction; cellular response to leukemia inhibitory factor; and negative regulation of acid-sensing ion channel activity. Located in cytoplasmic vesicle and plasma membrane. Orthologous to human STOML1 (stomatin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 21.3), whole brain E14.5 (RPKM 15.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 31.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58160443..58169807)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58253160..58262524)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10552 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat 2 Neighboring gene microRNA 6385 Neighboring gene promyelocytic leukemia Neighboring gene STARR-positive B cell enhancer ABC_E2891 Neighboring gene STARR-positive B cell enhancer ABC_E5071 Neighboring gene STARR-positive B cell enhancer ABC_E9764 Neighboring gene STARR-positive B cell enhancer ABC_E5072 Neighboring gene STARR-positive B cell enhancer ABC_E3836 Neighboring gene STARR-positive B cell enhancer ABC_E5073 Neighboring gene STARR-positive B cell enhancer ABC_E3837 Neighboring gene STARR-seq mESC enhancer starr_24273 Neighboring gene lysyl oxidase-like 1 Neighboring gene predicted gene, 53526

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. Kozlenkov A, et al. J Physiol, 2014 Feb 15. PMID 24247984, Free PMC Article
  2. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article
  3. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Fenske TS, et al. Cancer Res, 2006 May 15. PMID 16707424
  4. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STOML1 modulates ASIC1a and ASIC3 in DRG neurons.
    Title: Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC13700

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ion channel inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
stomatin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026942.3 → NP_081218.3  stomatin-like protein 1

    See identical proteins and their annotated locations for NP_081218.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC160976, AK045820, BE947366, CJ151482
    Consensus CDS
    CCDS23241.1
    UniProtKB/Swiss-Prot
    Q8BLA3, Q8CI66
    UniProtKB/TrEMBL
    A0A0B4J1F1
    Related
    ENSMUSP00000034883.6, ENSMUST00000034883.7
    Conserved Domains (3) summary
    smart00244
    Location:77 → 217
    PHB; prohibitin homologues
    cd13436
    Location:94 → 224
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:305 → 396
    SCP2; SCP-2 sterol transfer family

RNA

  1. NR_028146.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the coding region. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC160976, BE947366
    Related
    ENSMUST00000216877.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    58160443..58169807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511402.4 → XP_006511465.1  stomatin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511465.1

    Conserved Domains (2) summary
    cd13436
    Location:7 → 137
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:225 → 309
    SCP2; SCP-2 sterol transfer family

  2. XM_030244558.2 → XP_030100418.1  stomatin-like protein 1 isoform X1

    Conserved Domains (2) summary
    cd13436
    Location:7 → 137
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:225 → 309
    SCP2; SCP-2 sterol transfer family

  3. XM_006511404.4 → XP_006511467.1  stomatin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511467.1

    Conserved Domains (2) summary
    cd13436
    Location:7 → 137
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:225 → 309
    SCP2; SCP-2 sterol transfer family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CI66.1 GenPept UniProtKB/Swiss-Prot:Q8CI66

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