Oxa1l oxidase assembly 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oxa1lprovided by MGI
Official Full Name: oxidase assembly 1-likeprovided by MGI
Primary source: MGI:MGI:1916339
See related: Ensembl:ENSMUSG00000000959 AllianceGenome:MGI:1916339
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810020M02Rik
Summary: Predicted to enable membrane insertase activity; mitochondrial ribosome binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrion organization; negative regulation of ATPase activity; and protein tetramerization. Located in mitochondrial inner membrane. Orthologous to human OXA1L (OXA1L mitochondrial inner membrane protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 141.2), ovary adult (RPKM 84.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.76 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54598298..54607130)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54360841..54369669)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI894287 (e-PCR)
- UniSTS:165905

NoName (e-PCR)
- UniSTS:237182

BB370826 (e-PCR)
- UniSTS:209035

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables membrane insertase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrial ribosome binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial proton-transporting ATP synthase complex assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into mitochondrial inner membrane from matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial inner membrane protein OXA1L

Names: OXA1-like protein; oxidase assembly 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026936.4 → NP_081212.1 mitochondrial inner membrane protein OXA1L

See identical proteins and their annotated locations for NP_081212.1

Status: VALIDATED

Source sequence(s)

AC206013

Consensus CDS

CCDS27086.1

UniProtKB/Swiss-Prot

Q8BGA9, Q8BK01, Q8R091, Q9D8X7

UniProtKB/TrEMBL

Q3UTE7

Related

ENSMUSP00000000985.6, ENSMUST00000000985.7

Conserved Domains (1) summary

COG0706
Location:74 → 324

YidC; Membrane protein insertase Oxa1/YidC/SpoIIIJ, required for the localization of integral membrane proteins [Cell wall/membrane/envelope biogenesis]