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Psmd11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [ Mus musculus (house mouse) ]

Gene ID: 69077, updated on 5-Mar-2024

Summary

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Official Symbol
Psmd11provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11provided by MGI
Primary source
MGI:MGI:1916327
See related
Ensembl:ENSMUSG00000017428 AllianceGenome:MGI:1916327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S9; P44.5; 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik
Summary
Predicted to enable structural molecule activity. Predicted to be involved in proteasome assembly; stem cell differentiation; and ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in central nervous system; heart; neural retina; and skeletal muscle. Orthologous to human PSMD11 (proteasome 26S subunit, non-ATPase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.8), liver E14 (RPKM 25.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 47.89 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80319441..80364074)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80428615..80473248)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5730455P16 gene Neighboring gene STARR-positive B cell enhancer ABC_E7026 Neighboring gene STARR-seq mESC enhancer starr_30146 Neighboring gene zinc finger protein 207 Neighboring gene STARR-seq mESC enhancer starr_30149 Neighboring gene cyclin dependent kinase 5, regulatory subunit 1 Neighboring gene predicted gene, 53690 Neighboring gene myosin ID

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation and identification of a conditional knockout allele for the PSMD11 gene in mice. Zhao L, et al. BMC Dev Biol, 2021 Feb 1. PMID 33517884, Free PMC Article
  2. GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Gaillard S, et al. Neuron, 2014 Oct 1. PMID 25242222, Free PMC Article
  3. An epigenetic circuit controls neurogenic programs during neocortex development. Wang A, et al. Development, 2021 Nov 15. PMID 35020876
  4. Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. Hamazaki J, et al. PLoS Genet, 2015 Jul. PMID 26222436, Free PMC Article
  5. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Kim J, et al. Mol Cell Biol, 2020 Oct 13. PMID 32839293, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.
    Title: Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome accessory complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 11
Names
26S proteasome regulatory subunit RPN6
26S proteasome regulatory subunit S9
26S proteasome regulatory subunit p44.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178616.3 → NP_848731.2  26S proteasome non-ATPase regulatory subunit 11

    See identical proteins and their annotated locations for NP_848731.2

    Status: VALIDATED

    Source sequence(s)
    AK136049, BC119138, BY092952
    Consensus CDS
    CCDS25133.1
    UniProtKB/Swiss-Prot
    Q8BG32
    UniProtKB/TrEMBL
    Q3THG2, Q3UWW9, Q5BKQ9
    Related
    ENSMUSP00000017572.8, ENSMUST00000017572.14
    Conserved Domains (1) summary
    COG5159
    Location:17 → 421
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80319441..80364074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249223.4 → XP_011247525.1  26S proteasome non-ATPase regulatory subunit 11 isoform X1

    UniProtKB/TrEMBL
    Q8K2N7
    Conserved Domains (1) summary
    COG5159
    Location:28 → 343
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG32.3 GenPept UniProtKB/Swiss-Prot:Q8BG32

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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