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Pycr2 pyrroline-5-carboxylate reductase family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 69051, updated on 21-Apr-2024

Summary

Official Symbol
Pycr2provided by MGI
Official Full Name
pyrroline-5-carboxylate reductase family, member 2provided by MGI
Primary source
MGI:MGI:1277956
See related
Ensembl:ENSMUSG00000026520 AllianceGenome:MGI:1277956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P5cr2; 1810018M05Rik
Summary
Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process and cellular response to oxidative stress. Predicted to act upstream of or within cellular amino acid biosynthetic process. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 10. Orthologous to human PYCR2 (pyrroline-5-carboxylate reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 34.4), ovary adult (RPKM 30.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
1 H4; 1 84.46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180731839..180735653)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180904274..180908088)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182805483-182805670 Neighboring gene predicted gene, 39714 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182814007-182814116 Neighboring gene STARR-seq mESC enhancer starr_03220 Neighboring gene left-right determination factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2592 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182834193-182834494 Neighboring gene predicted gene, 32199 Neighboring gene STARR-positive B cell enhancer ABC_E10069 Neighboring gene STARR-seq mESC enhancer starr_03222 Neighboring gene predicted gene, 39715 Neighboring gene left right determination factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in proline biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pyrroline-5-carboxylate reductase 2
Names
P5C reductase 2
P5CR 2
NP_598466.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133705.2NP_598466.1  pyrroline-5-carboxylate reductase 2

    See identical proteins and their annotated locations for NP_598466.1

    Status: VALIDATED

    Source sequence(s)
    AI847678, AK165618, CJ154235
    Consensus CDS
    CCDS15576.1
    UniProtKB/Swiss-Prot
    Q922Q4
    UniProtKB/TrEMBL
    Q3TJ21, Q3TMZ1
    Related
    ENSMUSP00000027802.8, ENSMUST00000027802.9
    Conserved Domains (1) summary
    PLN02688
    Location:1268
    PLN02688; pyrroline-5-carboxylate reductase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    180731839..180735653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)