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Lyzl4 lysozyme-like 4 [ Mus musculus (house mouse) ]

Gene ID: 69032, updated on 5-Mar-2024

Summary

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Official Symbol
Lyzl4provided by MGI
Official Full Name
lysozyme-like 4provided by MGI
Primary source
MGI:MGI:1916282
See related
Ensembl:ENSMUSG00000032530 AllianceGenome:MGI:1916282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lyc4; Lyza; 1810009N24Rik
Summary
Predicted to enable lysozyme activity. Involved in fertilization. Located in acrosomal vesicle; extracellular space; and sperm flagellum. Is expressed in craniocervical region bone; ganglia; medulla oblongata basal plate mantle layer; and stomach. Orthologous to human LYZL4 (lysozyme like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 38.8) See more
Orthologs
human all
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Genomic context

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Location:
9 F4; 9 72.45 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121406907..121471187, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121577841..121642121, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38661 Neighboring gene cholecystokinin Neighboring gene predicted gene, 47095 Neighboring gene lysozyme-like 4, opposite strand Neighboring gene STARR-seq mESC enhancer starr_25538 Neighboring gene vasoactive intestinal peptide receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E10592 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121591571-121591680 Neighboring gene STARR-positive B cell enhancer mm9_chr9:121606658-121606959 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene STARR-positive B cell enhancer ABC_E11426

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lyzl4, a novel mouse sperm-related protein, is involved in fertilization. Sun R, et al. Acta Biochim Biophys Sin (Shanghai), 2011 May. PMID 21444326
  2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysozyme-like protein 4
Names
lysozyme a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357346.2 → NP_001344275.2  lysozyme-like protein 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131660, AC159810
    UniProtKB/Swiss-Prot
    Q9D925
    UniProtKB/TrEMBL
    A0A1L1SV59, Q78ID0
    Related
    ENSMUSP00000113034.2, ENSMUST00000120918.8
    Conserved Domains (1) summary
    cd16897
    Location:21 → 143
    LYZ_C; C-type lysozyme

  2. NM_001382835.1 → NP_001369764.1  lysozyme-like protein 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131660
    UniProtKB/Swiss-Prot
    Q9D925
    UniProtKB/TrEMBL
    A0A1L1SV59, Q78ID0
    Related
    ENSMUSP00000151031.2, ENSMUST00000213757.2
    Conserved Domains (1) summary
    cd16897
    Location:21 → 143
    LYZ_C; C-type lysozyme

  3. NM_026915.4 → NP_081191.1  lysozyme-like protein 4 precursor

    See identical proteins and their annotated locations for NP_081191.1

    Status: VALIDATED

    Source sequence(s)
    AC131660, AC159810
    Consensus CDS
    CCDS23632.1
    UniProtKB/Swiss-Prot
    Q9D925
    UniProtKB/TrEMBL
    A0A1L1SV59, Q78ID0
    Related
    ENSMUSP00000076887.4, ENSMUST00000077706.10
    Conserved Domains (1) summary
    cd16897
    Location:21 → 143
    LYZ_C; C-type lysozyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121406907..121471187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512248.2 → XP_006512311.1  lysozyme-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006512311.1

    UniProtKB/Swiss-Prot
    Q9D925
    UniProtKB/TrEMBL
    A0A1L1SV59, Q78ID0
    Conserved Domains (1) summary
    cd16897
    Location:21 → 143
    LYZ_C; C-type lysozyme
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D925.3 GenPept UniProtKB/Swiss-Prot:Q9D925

Gene LinkOut

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