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Smdt1 single-pass membrane protein with aspartate rich tail 1 [ Mus musculus (house mouse) ]

Gene ID: 69029, updated on 5-Mar-2024

Summary

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Official Symbol
Smdt1provided by MGI
Official Full Name
single-pass membrane protein with aspartate rich tail 1provided by MGI
Primary source
MGI:MGI:1916279
See related
Ensembl:ENSMUSG00000022452 AllianceGenome:MGI:1916279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emre; 1500032L24Rik
Summary
Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to act upstream of or within calcium ion transport. Located in mitochondrion. Is expressed in nervous system; neural retina; orbito-sphenoid; and vibrissa. Orthologous to human SMDT1 (single-pass membrane protein with aspartate rich tail 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 154.0), duodenum adult (RPKM 148.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Smdt1 in Genome Data Viewer
Location:
15 E1; 15 38.56 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82229901..82233266)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82346046..82349062)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene N-acetyl galactosaminidase, alpha Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_39293 Neighboring gene nuclear encoded rRNA 5S 41 Neighboring gene NADH:ubiquinone oxidoreductase subunit A6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82192158-82192359 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Liu JC, et al. Cell Rep, 2016 Aug 9. PMID 27477272, Free PMC Article
  2. Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle. De La Fuente S, et al. J Biol Chem, 2016 Oct 28. PMID 27637331, Free PMC Article
  3. EMRE is essential for mitochondrial calcium uniporter activity in a mouse model. Liu JC, et al. JCI Insight, 2020 Feb 27. PMID 32017711, Free PMC Article
  4. Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients. Singh R, et al. Sci Adv, 2022 Mar 18. PMID 35302860, Free PMC Article
  5. EMRE is an essential component of the mitochondrial calcium uniporter complex. Sancak Y, et al. Science, 2013 Dec 13. PMID 24231807, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term.
    Title: Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term.
  2. MCU and EMRE proteins were mainly targeting to the IMM-outer mitochondrial membrane.
    Title: Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC106724

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium import into the mitochondrion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of uniplex complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
essential MCU regulator, mitochondrial
Names
UPF0466 protein C22orf32 homolog, mitochondrial
single-pass membrane protein with aspartate-rich tail 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026914.1 → NP_081190.1  essential MCU regulator, mitochondrial precursor

    See identical proteins and their annotated locations for NP_081190.1

    Status: PROVISIONAL

    Source sequence(s)
    BC028457
    Consensus CDS
    CCDS27688.1
    UniProtKB/Swiss-Prot
    Q58EA5, Q9DB10
    Related
    ENSMUSP00000023086.9, ENSMUST00000023086.15
    Conserved Domains (1) summary
    pfam10161
    Location:33 → 101
    DDDD; Putative mitochondrial precursor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82229901..82233266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159567.1 → XP_036015460.1  essential MCU regulator, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q58EA5, Q9DB10
    Conserved Domains (1) summary
    pfam10161
    Location:33 → 101
    DDDD; Putative mitochondrial precursor protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB10.1 GenPept UniProtKB/Swiss-Prot:Q9DB10

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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