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Snx15 sorting nexin 15 [ Mus musculus (house mouse) ]

Gene ID: 69024, updated on 5-Mar-2024

Summary

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Official Symbol
Snx15provided by MGI
Official Full Name
sorting nexin 15provided by MGI
Primary source
MGI:MGI:1916274
See related
Ensembl:ENSMUSG00000024787 AllianceGenome:MGI:1916274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500032B08Rik; E130013C21Rik
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in early endosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human SNX15 (sorting nexin 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 16.5), liver E14 (RPKM 14.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6169429..6182446, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6119399..6132415, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene N-acetylated alpha-linked acidic dipeptidase-like 1 Neighboring gene STARR-seq mESC enhancer starr_45420 Neighboring gene SAC3 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E11014 Neighboring gene predicted gene, 57660 Neighboring gene microRNA 12193 Neighboring gene ADP-ribosylation factor-like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6141140-6141385 Neighboring gene predicted pseudogene 5510

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. Feng T, et al. Mol Neurobiol, 2016 Aug. PMID 26115702, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026912.2 → NP_081188.1  sorting nexin-15

    See identical proteins and their annotated locations for NP_081188.1

    Status: VALIDATED

    Source sequence(s)
    AI850984, BC016091, BY289304
    Consensus CDS
    CCDS29495.1
    UniProtKB/Swiss-Prot
    Q91WE1
    Related
    ENSMUSP00000025702.8, ENSMUST00000025702.14
    Conserved Domains (2) summary
    cd02677
    Location:267 → 337
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl02563
    Location:9 → 126
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6169429..6182446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531831.5 → XP_006531894.1  sorting nexin-15 isoform X1

    See identical proteins and their annotated locations for XP_006531894.1

    UniProtKB/Swiss-Prot
    Q91WE1
    Conserved Domains (2) summary
    cd02677
    Location:267 → 337
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl02563
    Location:9 → 126
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. XM_011248651.4 → XP_011246953.1  sorting nexin-15 isoform X2

    UniProtKB/TrEMBL
    D3Z479
    Related
    ENSMUSP00000122740.2, ENSMUST00000154601.8
    Conserved Domains (1) summary
    cl02563
    Location:9 → 126
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WE1.1 GenPept UniProtKB/Swiss-Prot:Q91WE1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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