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Anapc10 anaphase promoting complex subunit 10 [ Mus musculus (house mouse) ]

Gene ID: 68999, updated on 5-Mar-2024

Summary

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Official Symbol
Anapc10provided by MGI
Official Full Name
anaphase promoting complex subunit 10provided by MGI
Primary source
MGI:MGI:1916249
See related
Ensembl:ENSMUSG00000036977 AllianceGenome:MGI:1916249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APC10; 1500026N15Rik; A830003M23Rik
Summary
Predicted to be involved in protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Located in cytoplasm. Orthologous to human ANAPC10 (anaphase promoting complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 2.3), CNS E14 (RPKM 2.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C1; 8 37.79 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (80438366..80503950)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79711736..79777321)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51579 Neighboring gene OTU domain containing 4 Neighboring gene tumor protein D52, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9318 Neighboring gene STARR-seq mESC enhancer starr_22015 Neighboring gene ATP-binding cassette, sub-family E member 1 Neighboring gene STARR-seq mESC enhancer starr_22017 Neighboring gene STARR-positive B cell enhancer ABC_E9118 Neighboring gene STARR-seq mESC enhancer starr_22019 Neighboring gene STARR-seq mESC enhancer starr_22022 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 30494 Neighboring gene STARR-seq mESC enhancer starr_22024 Neighboring gene STARR-seq mESC enhancer starr_22025 Neighboring gene STARR-seq mESC enhancer starr_22026 Neighboring gene Hedgehog-interacting protein Neighboring gene predicted gene, 39206

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Zhao S, et al. Dev Cell, 2013 Jan 14. PMID 23328397
  2. Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice. Ray D, et al. Biol Reprod, 2012 Apr. PMID 22190705, Free PMC Article
  3. Oligosyndactylism mice have an inversion of chromosome 8. Wise TL, et al. Genetics, 2004 Dec. PMID 15611179, Free PMC Article
  4. The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. Shoji S, et al. FEBS Open Bio, 2014. PMID 25161877, Free PMC Article
  5. Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ. Saito K, et al. iScience, 2020 Jul 24. PMID 32674056, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANAPC10 was mainly expressed in the cytoplasm of spermatogonia and leptotene and pachytene spermatocytes.
    Title: Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
part_of anaphase-promoting complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
anaphase-promoting complex subunit 10
Names
cyclosome subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357234.1 → NP_001344163.1  anaphase-promoting complex subunit 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101714, AC158348, BB647573
    Consensus CDS
    CCDS22439.1
    UniProtKB/Swiss-Prot
    Q8K2H6, Q9CW24
    Conserved Domains (1) summary
    pfam03256
    Location:4 → 183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

  2. NM_001357235.1 → NP_001344164.1  anaphase-promoting complex subunit 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101714, AC158348, AK041373
    Consensus CDS
    CCDS22439.1
    UniProtKB/Swiss-Prot
    Q8K2H6, Q9CW24
    Related
    ENSMUSP00000148220.2, ENSMUST00000210812.2
    Conserved Domains (1) summary
    pfam03256
    Location:4 → 183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

  3. NM_001357236.1 → NP_001344165.1  anaphase-promoting complex subunit 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101714, AC158348, BQ178177
    Consensus CDS
    CCDS22439.1
    UniProtKB/Swiss-Prot
    Q8K2H6, Q9CW24
    Conserved Domains (1) summary
    pfam03256
    Location:4 → 183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

  4. NM_001357237.1 → NP_001344166.1  anaphase-promoting complex subunit 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101714, AC158348, BE863817
    Conserved Domains (1) summary
    cl02148
    Location:4 → 111
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  5. NM_026904.3 → NP_081180.1  anaphase-promoting complex subunit 10 isoform a

    See identical proteins and their annotated locations for NP_081180.1

    Status: VALIDATED

    Source sequence(s)
    AC101714, AC158348, AK005303, CX567202
    Consensus CDS
    CCDS22439.1
    UniProtKB/Swiss-Prot
    Q8K2H6, Q9CW24
    Related
    ENSMUSP00000048244.8, ENSMUST00000048147.9
    Conserved Domains (1) summary
    pfam03256
    Location:4 → 183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    80438366..80503950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243749.2 → XP_030099609.1  anaphase-promoting complex subunit 10 isoform X1

    Conserved Domains (1) summary
    cl02148
    Location:4 → 69
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  2. XM_006531342.2 → XP_006531405.1  anaphase-promoting complex subunit 10 isoform X2

    See identical proteins and their annotated locations for XP_006531405.1

    Conserved Domains (1) summary
    cl02148
    Location:4 → 111
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  3. XM_030243751.1 → XP_030099611.1  anaphase-promoting complex subunit 10 isoform X3

    Conserved Domains (1) summary
    cl02148
    Location:4 → 69
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  4. XM_036154264.1 → XP_036010157.1  anaphase-promoting complex subunit 10 isoform X1

    Conserved Domains (1) summary
    cl02148
    Location:4 → 69
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  5. XM_036154266.1 → XP_036010159.1  anaphase-promoting complex subunit 10 isoform X3

    Conserved Domains (1) summary
    cl02148
    Location:4 → 69
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  6. XM_036154265.1 → XP_036010158.1  anaphase-promoting complex subunit 10 isoform X2

    Conserved Domains (1) summary
    cl02148
    Location:4 → 111
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  7. XM_030243750.1 → XP_030099610.1  anaphase-promoting complex subunit 10 isoform X1

    Conserved Domains (1) summary
    cl02148
    Location:4 → 69
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2H6.1 GenPept UniProtKB/Swiss-Prot:Q8K2H6

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