U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Haghl hydroxyacylglutathione hydrolase-like [ Mus musculus (house mouse) ]

Gene ID: 68977, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Haghlprovided by MGI
Official Full Name
hydroxyacylglutathione hydrolase-likeprovided by MGI
Primary source
MGI:MGI:1919877
See related
Ensembl:ENSMUSG00000061046 AllianceGenome:MGI:1919877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500017E18Rik; 2810014I23Rik; C330022E15Rik
Summary
Predicted to enable hydroxyacylglutathione hydrolase activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Is expressed in several structures, including eye; forelimb bud; nervous system; and respiratory system. Orthologous to human HAGHL (hydroxyacylglutathione hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 50.2), CNS E14 (RPKM 37.3) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 A3.3; 17 12.88 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25998817..26004560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25779843..25785586, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mesothelin Neighboring gene STARR-seq mESC enhancer starr_42110 Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene microRNA 6966 Neighboring gene STARR-positive B cell enhancer ABC_E5579 Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  2. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC101974

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacylglutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
hydroxyacylglutathione hydrolase-like protein
NP_001258362.1
NP_001258363.1
NP_001258364.1
NP_001258365.1
NP_001258366.1
NP_001365709.1
NP_001365710.1
NP_001365711.1
NP_001365712.1
NP_001365713.1
NP_081173.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271433.1 → NP_001258362.1  hydroxyacylglutathione hydrolase-like protein isoform a

    See identical proteins and their annotated locations for NP_001258362.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AI844861, BC083322, BY265614
    Consensus CDS
    CCDS28527.1
    UniProtKB/Swiss-Prot
    Q8C8C4, Q9DB32
    Related
    ENSMUSP00000077091.4, ENSMUST00000077938.10
    Conserved Domains (3) summary
    PLN02469
    Location:1 → 245
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:174 → 252
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4 → 173
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

  2. NM_001271434.1 → NP_001258363.1  hydroxyacylglutathione hydrolase-like protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI844861, AK012748, BY265614
    Related
    ENSMUST00000137587.8
    Conserved Domains (2) summary
    pfam16123
    Location:174 → 201
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4 → 173
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

  3. NM_001271435.1 → NP_001258364.1  hydroxyacylglutathione hydrolase-like protein isoform c

    See identical proteins and their annotated locations for NP_001258364.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 3' UTR and 3' coding region compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK047517, BY265614
    Consensus CDS
    CCDS70773.1
    UniProtKB/Swiss-Prot
    Q9DB32
    Related
    ENSMUSP00000116841.2, ENSMUST00000140738.8
    Conserved Domains (3) summary
    COG0491
    Location:1 → 226
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    pfam16123
    Location:174 → 229
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4 → 173
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

  4. NM_001271436.1 → NP_001258365.1  hydroxyacylglutathione hydrolase-like protein isoform d

    See identical proteins and their annotated locations for NP_001258365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 5 and 6 encode the same isoform (d).
    Source sequence(s)
    AI844861, AK012748, AK021220, BY265614
    Consensus CDS
    CCDS70772.1
    UniProtKB/TrEMBL
    D3YZU6
    Related
    ENSMUSP00000120885.2, ENSMUST00000133071.8
    Conserved Domains (2) summary
    pfam16123
    Location:126 → 204
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:1 → 125
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

  5. NM_001271437.1 → NP_001258366.1  hydroxyacylglutathione hydrolase-like protein isoform d

    See identical proteins and their annotated locations for NP_001258366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 5 and 6 encode the same isoform (d).
    Source sequence(s)
    AI844861, AK012748, AK021220, BY265614
    Consensus CDS
    CCDS70772.1
    UniProtKB/TrEMBL
    D3YZU6
    Related
    ENSMUSP00000115538.2, ENSMUST00000138759.8
    Conserved Domains (2) summary
    pfam16123
    Location:126 → 204
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:1 → 125
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

  6. NM_001378780.1 → NP_001365709.1  hydroxyacylglutathione hydrolase-like protein isoform f

    Status: VALIDATED

    Source sequence(s)
    AC134908
    Conserved Domains (1) summary
    PLN02469
    Location:1 → 272
    PLN02469; hydroxyacylglutathione hydrolase

  7. NM_001378781.1 → NP_001365710.1  hydroxyacylglutathione hydrolase-like protein isoform e

    Status: VALIDATED

    Source sequence(s)
    AC134908
    Related
    ENSMUST00000129917.8
    Conserved Domains (1) summary
    PLN02469
    Location:1 → 254
    PLN02469; hydroxyacylglutathione hydrolase

  8. NM_001378782.1 → NP_001365711.1  hydroxyacylglutathione hydrolase-like protein isoform g

    Status: VALIDATED

    Source sequence(s)
    AC134908
    Conserved Domains (1) summary
    PLN02469
    Location:1 → 227
    PLN02469; hydroxyacylglutathione hydrolase

  9. NM_001378783.1 → NP_001365712.1  hydroxyacylglutathione hydrolase-like protein isoform h

    Status: VALIDATED

    Source sequence(s)
    AC134908
    Conserved Domains (1) summary
    PLN02469
    Location:1 → 179
    PLN02469; hydroxyacylglutathione hydrolase

  10. NM_001378784.1 → NP_001365713.1  hydroxyacylglutathione hydrolase-like protein isoform h

    Status: VALIDATED

    Source sequence(s)
    AC134908
    Conserved Domains (1) summary
    PLN02469
    Location:1 → 179
    PLN02469; hydroxyacylglutathione hydrolase

  11. NM_026897.3 → NP_081173.1  hydroxyacylglutathione hydrolase-like protein isoform a

    See identical proteins and their annotated locations for NP_081173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AI844861, AK005274, BY293803
    Consensus CDS
    CCDS28527.1
    UniProtKB/Swiss-Prot
    Q8C8C4, Q9DB32
    Related
    ENSMUSP00000119647.2, ENSMUST00000150324.8
    Conserved Domains (3) summary
    PLN02469
    Location:1 → 245
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:174 → 252
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4 → 173
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25998817..26004560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB32.1 GenPept UniProtKB/Swiss-Prot:Q9DB32

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous