U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dcaf12 DDB1 and CUL4 associated factor 12 [ Mus musculus (house mouse) ]

Gene ID: 68970, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Dcaf12provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 12provided by MGI
Primary source
MGI:MGI:1916220
See related
Ensembl:ENSMUSG00000028436 AllianceGenome:MGI:1916220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr40a; 1500001L20Rik; 5830424K06Rik
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in centrosome and cytoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF12 (DDB1 and CUL4 associated factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 28.9), liver E14 (RPKM 16.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 A5; 4 21.32 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41291300..41316749, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41291300..41316749, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated protein 2 Neighboring gene predicted gene 12401 Neighboring gene STARR-positive B cell enhancer ABC_E2108 Neighboring gene predicted gene, 42273 Neighboring gene STARR-positive B cell enhancer ABC_E7963 Neighboring gene STARR-positive B cell enhancer ABC_E6163 Neighboring gene predicted gene, 26049 Neighboring gene STARR-seq mESC enhancer starr_10032 Neighboring gene predicted gene, 46891 Neighboring gene STARR-positive B cell enhancer mm9_chr4:41295845-41296146 Neighboring gene predicted gene, 26084 Neighboring gene ubiquitin-associated protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. Lidak T, et al. Int J Mol Sci, 2021 May 20. PMID 34065512, Free PMC Article
  2. DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. Zhang YL, et al. EMBO J, 2018 Sep 14. PMID 30111536, Free PMC Article
  3. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
  4. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DDB1- and CUL4-associated factor 12
Names
WD repeat domain 40A
WD repeat-containing protein 40A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026893.3 → NP_081169.2  DDB1- and CUL4-associated factor 12

    See identical proteins and their annotated locations for NP_081169.2

    Status: VALIDATED

    Source sequence(s)
    AA207929, AK031089, AK173289, BY338453
    Consensus CDS
    CCDS18059.1
    UniProtKB/Swiss-Prot
    Q69Z77, Q8BGZ3, Q8BN60, Q8C1Y4, Q9DB95
    Related
    ENSMUSP00000030145.9, ENSMUST00000030145.9
    Conserved Domains (3) summary
    COG2319
    Location:103 → 378
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:144 → 180
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:85 → 279
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41291300..41316749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538230.4 → XP_006538293.1  DDB1- and CUL4-associated factor 12 isoform X4

    See identical proteins and their annotated locations for XP_006538293.1

  2. XM_006538229.4 → XP_006538292.1  DDB1- and CUL4-associated factor 12 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:120 → 156
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:61 → 255
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006538228.4 → XP_006538291.1  DDB1- and CUL4-associated factor 12 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:138 → 174
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:79 → 273
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_036164402.1 → XP_036020295.1  DDB1- and CUL4-associated factor 12 isoform X4

  5. XM_017320381.3 → XP_017175870.1  DDB1- and CUL4-associated factor 12 isoform X4

  6. XM_036164401.1 → XP_036020294.1  DDB1- and CUL4-associated factor 12 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:90 → 130
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:85 → 297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGZ3.1 GenPept UniProtKB/Swiss-Prot:Q8BGZ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous