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Rasl11b RAS-like, family 11, member B [ Mus musculus (house mouse) ]

Gene ID: 68939, updated on 5-Mar-2024

Summary

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Official Symbol
Rasl11bprovided by MGI
Official Full Name
RAS-like, family 11, member Bprovided by MGI
Primary source
MGI:MGI:1916189
See related
Ensembl:ENSMUSG00000049907 AllianceGenome:MGI:1916189
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190017B18Rik
Summary
Enables transforming growth factor beta receptor binding activity. Acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in membrane. Is expressed in limb mesenchyme; lung; musculoskeletal system; sensory organ; and vibrissa. Orthologous to human RASL11B (RAS like family 11 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 48.9), limb E14.5 (RPKM 38.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.3; 5 39.43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (74355987..74360138)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (74195326..74199477)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 26 Neighboring gene differentiation antagonizing non-protein coding RNA Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74596657-74596859 Neighboring gene predicted gene, 32002 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74656347-74656530 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74656616-74656725 Neighboring gene Sec1 family domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_13406 Neighboring gene predicted gene, 32064 Neighboring gene VISTA enhancer mm139 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74762842-74763025 Neighboring gene STARR-seq mESC enhancer starr_13407 Neighboring gene STARR-positive B cell enhancer ABC_E2746 Neighboring gene STARR-positive B cell enhancer ABC_E6339 Neighboring gene factor interacting with PAPOLA and CPSF1 Neighboring gene ligand of numb-protein X 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta. Piek E, et al. Biochem J, 2004 Oct 1. PMID 15239668, Free PMC Article
  2. Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Hupe M, et al. Nucleic Acids Res, 2014 Jan. PMID 24165879, Free PMC Article
  3. Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. Boyle MP, et al. J Comp Neurol, 2011 Aug 1. PMID 21491433
  4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC103217

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ras-like protein family member 11B
NP_081154.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026878.1 → NP_081154.1  ras-like protein family member 11B

    See identical proteins and their annotated locations for NP_081154.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083068
    Consensus CDS
    CCDS39113.1
    UniProtKB/Swiss-Prot
    Q922H7, Q9D0S0
    Related
    ENSMUSP00000053389.7, ENSMUST00000051937.9
    Conserved Domains (2) summary
    cd04146
    Location:34 → 201
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
    smart00173
    Location:34 → 200
    RAS; Ras subfamily of RAS small GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    74355987..74360138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922H7.1 GenPept UniProtKB/Swiss-Prot:Q922H7

Gene LinkOut

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