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Mospd3 motile sperm domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 68929, updated on 5-Mar-2024

Summary

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Official Symbol
Mospd3provided by MGI
Official Full Name
motile sperm domain containing 3provided by MGI
Primary source
MGI:MGI:1916179
See related
Ensembl:ENSMUSG00000037221 AllianceGenome:MGI:1916179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R124; Gtig2; 1190005J19Rik; 5133401H10Rik
Summary
Predicted to enable FFAT motif binding activity. Acts upstream of or within heart development. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Orthologous to human MOSPD3 (motile sperm domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 55.5), thymus adult (RPKM 49.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 76.59 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137594907..137599342, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137596645..137601079, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene actin-like 6B Neighboring gene transferrin receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2180 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138038199-138038386 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138041904-138042125 Neighboring gene STARR-positive B cell enhancer ABC_E281 Neighboring gene predicted gene 7285 Neighboring gene procollagen C-endopeptidase enhancer protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1. Yamaguchi T, et al. Brain Res, 2004 Oct 29. PMID 15464766
  2. Gene trap integrations expressed in the developing heart: insertion site affects splicing of the PT1-ATG vector. McClive P, et al. Dev Dyn, 1998 Jun. PMID 9626501
  3. A novel transmembrane MSP-containing protein that plays a role in right ventricle development. Pall GS, et al. Genomics, 2004 Dec. PMID 15533722
  4. An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro. Forrester LM, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643689, Free PMC Article
  5. Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. O'Leary J, et al. PLoS One, 2011. PMID 21909369, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
    Title: Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
motile sperm domain-containing protein 3
Names
gene trap integration gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001254762.1 → NP_001241691.1  motile sperm domain-containing protein 3

    See identical proteins and their annotated locations for NP_001241691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC148018, AW050147, BQ445267, CK617131
    Consensus CDS
    CCDS19771.1
    UniProtKB/Swiss-Prot
    Q8BGG6
    UniProtKB/TrEMBL
    Q05DT5
    Related
    ENSMUSP00000106636.2, ENSMUST00000111007.8
    Conserved Domains (1) summary
    pfam00635
    Location:41 → 133
    Motile_Sperm; MSP (Major sperm protein) domain

  2. NM_030037.2 → NP_084313.1  motile sperm domain-containing protein 3

    See identical proteins and their annotated locations for NP_084313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC148018, AI845922, AK004495, AK019892, BE861793, DV656015
    Consensus CDS
    CCDS19771.1
    UniProtKB/Swiss-Prot
    Q8BGG6
    UniProtKB/TrEMBL
    Q05DT5
    Related
    ENSMUSP00000040828.8, ENSMUST00000037620.14
    Conserved Domains (1) summary
    pfam00635
    Location:41 → 133
    Motile_Sperm; MSP (Major sperm protein) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137594907..137599342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504613.5 → XP_006504676.1  motile sperm domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006504676.1

    Conserved Domains (1) summary
    pfam00635
    Location:41 → 133
    Motile_Sperm; MSP (Major sperm protein) domain

  2. XM_006504614.5 → XP_006504677.1  motile sperm domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006504677.1

    UniProtKB/Swiss-Prot
    Q8BGG6
    UniProtKB/TrEMBL
    Q05DT5
    Conserved Domains (1) summary
    pfam00635
    Location:41 → 133
    Motile_Sperm; MSP (Major sperm protein) domain

  3. XM_006504612.2 → XP_006504675.1  motile sperm domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006504675.1

    Conserved Domains (1) summary
    pfam00635
    Location:41 → 133
    Motile_Sperm; MSP (Major sperm protein) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGG6.1 GenPept UniProtKB/Swiss-Prot:Q8BGG6

Gene LinkOut

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