U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ubap2 ubiquitin-associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68926, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ubap2provided by MGI
Official Full Name
ubiquitin-associated protein 2provided by MGI
Primary source
MGI:MGI:1916176
See related
Ensembl:ENSMUSG00000028433 AllianceGenome:MGI:1916176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UBAP-2; mKIAA1491; 1190005K07Rik
Summary
Predicted to be active in cytoplasm and nucleus. Orthologous to human UBAP2 (ubiquitin associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 65.5), thymus adult (RPKM 28.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 A5; 4 21.13 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41194313..41276016, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41194313..41276016, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E150 Neighboring gene STARR-positive B cell enhancer ABC_E6162 Neighboring gene nucleolar protein family 6 (RNA-associated) Neighboring gene ubiquitin-conjugating enzyme E2R 2 Neighboring gene STARR-seq mESC enhancer starr_10025 Neighboring gene predicted gene, 22888 Neighboring gene predicted gene, 24837 Neighboring gene predicted gene, 23090 Neighboring gene predicted gene 12401 Neighboring gene STARR-positive B cell enhancer ABC_E2108 Neighboring gene predicted gene, 42273 Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene STARR-positive B cell enhancer ABC_E7963 Neighboring gene predicted gene, 26049

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis. Kim J, et al. Nat Commun, 2023 Jun 20. PMID 37339951, Free PMC Article
  2. lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins. Kuniyoshi H, et al. Genetics, 2002 Dec. PMID 12524348, Free PMC Article
  3. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis.
    Title: Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis.
  2. UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis.
    Title: UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin-associated protein 2
Names
MLig-1
RNA polymerase II degradation factor Ubap2
protein lingerer homolog 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419187.1 → NP_001406116.1  ubiquitin-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807823

  2. NM_001419188.1 → NP_001406117.1  ubiquitin-associated protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL807823

  3. NM_001419189.1 → NP_001406118.1  ubiquitin-associated protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL807823
    Related
    ENSMUSP00000121724.2, ENSMUST00000134782.2

  4. NM_001419190.1 → NP_001406119.1  ubiquitin-associated protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL807823

  5. NM_001419191.1 → NP_001406120.1  ubiquitin-associated protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL807823

  6. NM_026872.2 → NP_081148.1  ubiquitin-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_081148.1

    Status: VALIDATED

    Source sequence(s)
    AL807823
    Consensus CDS
    CCDS18058.1
    UniProtKB/Swiss-Prot
    Q812D6, Q91VX2, Q99K40
    UniProtKB/TrEMBL
    A2AMY5
    Related
    ENSMUSP00000030143.7, ENSMUST00000030143.13
    Conserved Domains (2) summary
    cd14277
    Location:53 → 90
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:512 → 541
    DUF3697; Ubiquitin-associated protein 2

RNA

  1. NR_185031.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL807823

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41194313..41276016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538224.2 → XP_006538287.1  ubiquitin-associated protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006538287.1

    UniProtKB/Swiss-Prot
    Q812D6, Q91VX2, Q99K40
    UniProtKB/TrEMBL
    A2AMY5
    Conserved Domains (2) summary
    cd14277
    Location:53 → 90
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:512 → 541
    DUF3697; Ubiquitin-associated protein 2

  2. XM_006538225.5 → XP_006538288.1  ubiquitin-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    A2AMY5
    Conserved Domains (2) summary
    cd14277
    Location:59 → 96
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:518 → 547
    DUF3697; Ubiquitin-associated protein 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VX2.1 GenPept UniProtKB/Swiss-Prot:Q91VX2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous