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TAPBP TAP binding protein [ Homo sapiens (human) ]

Gene ID: 6892, updated on 7-Apr-2024

Summary

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Official Symbol
TAPBPprovided by HGNC
Official Full Name
TAP binding proteinprovided by HGNC
Primary source
HGNC:HGNC:11566
See related
Ensembl:ENSG00000231925 MIM:601962; AllianceGenome:HGNC:11566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPN; TAPA; TPSN; NGS17
Summary
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 38.1), appendix (RPKM 25.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6p21.32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33299694..33314078, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33121056..33135440, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33267471..33281855, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 46 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33255009-33255542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33255543-33256076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33256611-33257144 Neighboring gene microRNA 6873 Neighboring gene microRNA 6834 Neighboring gene prefoldin subunit 6 Neighboring gene ral guanine nucleotide dissociation stimulator like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33265070-33265597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33265684-33266184 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33266952-33267130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33267887-33268394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33268395-33268900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33282409-33283068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33283069-33283726 Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene uncharacterized LOC124901303 Neighboring gene death domain associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner. Walker-Sperling V, et al. Proc Natl Acad Sci U S A, 2022 Jul 19. PMID 35858344, Free PMC Article
  2. Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules. Lan H, et al. Nat Commun, 2021 Jul 9. PMID 34244493, Free PMC Article
  3. HLA tapasin independence: broader peptide repertoire and HIV control. Bashirova AA, et al. Proc Natl Acad Sci U S A, 2020 Nov 10. PMID 33097667, Free PMC Article
  4. Atomistic structure and dynamics of the human MHC-I peptide-loading complex. Fisette O, et al. Proc Natl Acad Sci U S A, 2020 Aug 25. PMID 32788370, Free PMC Article
  5. Correlation between low tapasin expression and impaired CD8+ T‑cell function in patients with chronic hepatitis B. Tang Y, et al. Mol Med Rep, 2016 Oct. PMID 27510296

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The downregulation of Tapasin in dendritic cell regulates CD8[+] T cell autophagy to hamper hepatitis B viral clearance in the induced pluripotent stem cell-derived hepatocyte organoid.
    Title: The downregulation of Tapasin in dendritic cell regulates CD8(+) T cell autophagy to hamper hepatitis B viral clearance in the induced pluripotent stem cell-derived hepatocyte organoid.
  2. Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner.
    Title: Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner.
  3. The role of MHC I protein dynamics in tapasin and TAPBPR-assisted immunopeptidome editing.
    Title: The role of MHC I protein dynamics in tapasin and TAPBPR-assisted immunopeptidome editing.
  4. Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules.
    Title: Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules.
  5. HLA tapasin independence: broader peptide repertoire and HIV control.
    Title: HLA tapasin independence: broader peptide repertoire and HIV control.
  6. Atomistic structure and dynamics of the human MHC-I peptide-loading complex.
    Title: Atomistic structure and dynamics of the human MHC-I peptide-loading complex.
  7. The results demonstrated that the mRNA expression levels of tapasin were significantly downregulated in patients with chronic hepatitis B (CHB) compared with in healthy controls and patients with acute hepatitis B Furthermore, the apoptotic rate of CD8+ T cells was increased in patients with CHB compared with in the other two groups.
    Title: Correlation between low tapasin expression and impaired CD8+ T‑cell function in patients with chronic hepatitis B.
  8. The disruption of TAP1 and TAPBP generates pluripotent embryonic stem cells with reduced immunogenicity.
    Title: Generating hESCs with reduced immunogenicity by disrupting TAP1 or TAPBP.
  9. Fluctuation and entropy analyses show how tapasin chaperones major histocompatibility complex class I by stabilising it in a peptide-receptive conformation.
    Title: Molecular mechanism of peptide editing in the tapasin-MHC I complex.
  10. reduction in tapasin expression is associated with tumor progression in colorectal cancer
    Title: Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
MHC class I deficiency
MedGen: C1858266 OMIM: 604571 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TAPBP; predicted interaction to be involved in antigenicity/immunity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC class I protein binding TAS
Traceable Author Statement
more info
 PubMed 
enables MHC class I protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TAP complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TAP complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables TAP1 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables TAP1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables TAP1 binding TAS
Traceable Author Statement
more info
 PubMed 
enables TAP2 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables TAP2 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables TAP2 binding TAS
Traceable Author Statement
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide antigen binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in MHC class Ib protein complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide antigen assembly with MHC class I protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide antigen assembly with MHC class I protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide antigen stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein complex stability IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MHC class I peptide loading complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MHC class I peptide loading complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MHC class I peptide loading complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of Tapasin-ERp57 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in endoplasmic reticulum IC
Inferred by Curator
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
  
located_in lumenal side of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tapasin
Names
NGS-17
TAP binding protein (tapasin)
TAP-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009876.1 RefSeqGene

    Range
    4826..19519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_114

mRNA and Protein(s)

  1. NM_001410875.1 → NP_001397804.1  tapasin isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662820
    Consensus CDS
    CCDS93889.1
    UniProtKB/TrEMBL
    A0A8V8TQC5
    Related
    ENSP00000514506.1, ENST00000699657.1

  2. NM_003190.5 → NP_003181.3  tapasin isoform 1 precursor

    See identical proteins and their annotated locations for NP_003181.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AB010639, AF029750, AL662820
    Consensus CDS
    CCDS34426.1
    UniProtKB/Swiss-Prot
    A2AB91, A2ABC0, B0V003, B0V0A6, B2ZUA4, E9PGM2, O15210, O15272, O15533, Q5STJ8, Q5STK6, Q5STQ5, Q5STQ6, Q66K65, Q96KK7, Q9HAN8, Q9UEE0, Q9UEE4, Q9UIZ6, Q9Y6K2
    UniProtKB/TrEMBL
    A0A024RCT1, A0A0G2JKZ1
    Related
    ENSP00000395701.2, ENST00000434618.7
    Conserved Domains (1) summary
    cl11960
    Location:260 → 391
    Ig; Immunoglobulin domain

  3. NM_172208.3 → NP_757345.2  tapasin isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AL662820, AU117273, AW028178, BC080574
    Consensus CDS
    CCDS34428.2
    UniProtKB/TrEMBL
    A0A0A0MSV9, A0A0G2JKZ1
    Related
    ENSP00000404833.2, ENST00000426633.6
    Conserved Domains (1) summary
    cl11960
    Location:255 → 391
    Ig; Immunoglobulin domain

  4. NM_172209.3 → NP_757346.2  tapasin isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AF029750, AL662820, AU117273, EU693375
    Consensus CDS
    CCDS34427.2
    UniProtKB/TrEMBL
    A0A0A0MT98, A0A0G2JKZ1
    Related
    ENSP00000419659.1, ENST00000489157.6
    Conserved Domains (1) summary
    cl11960
    Location:168 → 304
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    33299694..33314078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419272.1 → XP_047275228.1  tapasin isoform X3

  2. XM_047419271.1 → XP_047275227.1  tapasin isoform X2

  3. XM_011514828.4 → XP_011513130.1  tapasin isoform X1

    See identical proteins and their annotated locations for XP_011513130.1

    UniProtKB/TrEMBL
    A0A0G2JKZ1
    Conserved Domains (1) summary
    cl11960
    Location:255 → 391
    Ig; Immunoglobulin domain

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    4711179..4725561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329858.1 → XP_054185833.1  tapasin isoform X3

  2. XM_054329857.1 → XP_054185832.1  tapasin isoform X2

  3. XM_054329856.1 → XP_054185831.1  tapasin isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    4543212..4557593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330341.1 → XP_054186316.1  tapasin isoform X3

  2. XM_054330340.1 → XP_054186315.1  tapasin isoform X2

  3. XM_054330339.1 → XP_054186314.1  tapasin isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    4735630..4750012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330857.1 → XP_054186832.1  tapasin isoform X3

  2. XM_054330856.1 → XP_054186831.1  tapasin isoform X2

  3. XM_054330855.1 → XP_054186830.1  tapasin isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    4494115..4508505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331118.1 → XP_054187093.1  tapasin isoform X2

  2. XM_054331117.1 → XP_054187092.1  tapasin isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    33121056..33135440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356273.1 → XP_054212248.1  tapasin isoform X3

  2. XM_054356272.1 → XP_054212247.1  tapasin isoform X2

  3. XM_054356271.1 → XP_054212246.1  tapasin isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15533.2 GenPept UniProtKB/Swiss-Prot:O15533

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