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Disp1 dispatched RND transporter family member 1 [ Mus musculus (house mouse) ]

Gene ID: 68897, updated on 25-Apr-2024

Summary

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Official Symbol
Disp1provided by MGI
Official Full Name
dispatched RND transporter family member 1provided by MGI
Primary source
MGI:MGI:1916147
See related
Ensembl:ENSMUSG00000030768 AllianceGenome:MGI:1916147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DispA; 1190008H24Rik
Summary
Enables peptide transmembrane transporter activity. Acts upstream of or within several processes, including determination of left/right symmetry; patched ligand maturation; and smoothened signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; foot bone; notochord; and palatal shelf. Orthologous to human DISP1 (dispatched RND transporter family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 15.4), ovary adult (RPKM 8.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H5; 1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (182867828..183010257, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183086264..183221537, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03293 Neighboring gene STARR-seq mESC enhancer starr_03294 Neighboring gene toll-like receptor 5 Neighboring gene predicted gene, 33747 Neighboring gene protein phosphatase 2A inhibitor-2 I-2PP2A-related Neighboring gene family with sequence similarity 177 member B Neighboring gene predicted gene, 34287 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene axin interactor, dorsalization associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dispatched uses Na(+) flux to power release of lipid-modified Hedgehog. Wang Q, et al. Nature, 2021 Nov. PMID 34707294, Free PMC Article
  2. Disp1 regulates growth of mammalian long bones through the control of Ihh distribution. Tsiairis CD, et al. Dev Biol, 2008 May 15. PMID 18395198, Free PMC Article
  3. Cleavage activates dispatched for Sonic Hedgehog ligand release. Stewart DP, et al. Elife, 2018 Jan 23. PMID 29359685, Free PMC Article
  4. Patched1 and Patched2 inhibit Smoothened non-cell autonomously. Roberts B, et al. Elife, 2016 Aug 23. PMID 27552050, Free PMC Article
  5. Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH. Kantarci S, et al. Am J Med Genet A, 2010 Oct. PMID 20799323, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dispatched uses Na(+) flux to power release of lipid-modified Hedgehog.
    Title: Dispatched uses Na(+) flux to power release of lipid-modified Hedgehog.
  2. Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
    Title: Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
  3. The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells.
    Title: Cleavage activates dispatched for Sonic Hedgehog ligand release.
  4. Disp1 regulates growth of mammalian long bones through the control of Indian hedgehog distribution.
    Title: Disp1 regulates growth of mammalian long bones through the control of Ihh distribution.
  5. Disp1 has a role in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand
    Title: Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand.
  6. Shh signaling is required within the notochord to maintain Shh expression and to prevent notochord degeneration. Disp1, unlike Smo, is not required for this juxtacrine signaling by Shh.
    Title: Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.
  7. Disp is required for the movement of Hh protein from its sites of synthesis in mice
    Title: Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in diaphragm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within patched ligand maturation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within patched ligand maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within peptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein dispatched homolog 1
Names
dispatched A
dispatched homolog 1
mdispa
twelve-pass transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278218.1 → NP_001265147.1  protein dispatched homolog 1

    See identical proteins and their annotated locations for NP_001265147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC122792, BB732349, BC043102
    Consensus CDS
    CCDS56661.1
    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Related
    ENSMUSP00000141747.2, ENSMUST00000195372.2
    Conserved Domains (1) summary
    cl25655
    Location:434 → 1114
    Patched; Patched family

  2. NM_001278219.1 → NP_001265148.1  protein dispatched homolog 1

    See identical proteins and their annotated locations for NP_001265148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC122792, AK138276, BB732349, BC043102
    Consensus CDS
    CCDS56661.1
    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Conserved Domains (1) summary
    cl25655
    Location:434 → 1114
    Patched; Patched family

  3. NM_001278220.1 → NP_001265149.1  protein dispatched homolog 1

    See identical proteins and their annotated locations for NP_001265149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC122792, AY144589, BB732349, BC043102, BY792654
    Consensus CDS
    CCDS56661.1
    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Related
    ENSMUSP00000126742.2, ENSMUST00000171366.7
    Conserved Domains (1) summary
    cl25655
    Location:434 → 1114
    Patched; Patched family

  4. NM_026866.3 → NP_081142.3  protein dispatched homolog 1

    See identical proteins and their annotated locations for NP_081142.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC122792, AK138276, BB732349, BC043102
    Consensus CDS
    CCDS56661.1
    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Related
    ENSMUSP00000003035.6, ENSMUST00000003035.12
    Conserved Domains (1) summary
    cl25655
    Location:434 → 1114
    Patched; Patched family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    182867828..183010257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153394.1 → XP_036009287.1  protein dispatched homolog 1 isoform X3

    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Conserved Domains (1) summary
    cl25655
    Location:434 → 1114
    Patched; Patched family

  2. XM_006535596.5 → XP_006535659.1  protein dispatched homolog 1 isoform X2

    Conserved Domains (1) summary
    cl25655
    Location:468 → 1148
    Patched; Patched family

  3. XM_036153395.1 → XP_036009288.1  protein dispatched homolog 1 isoform X4

    Conserved Domains (1) summary
    cl25655
    Location:241 → 921
    Patched; Patched family

  4. XM_036153391.1 → XP_036009284.1  protein dispatched homolog 1 isoform X1

    Conserved Domains (1) summary
    cl25655
    Location:470 → 1150
    Patched; Patched family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TDN0.2 GenPept UniProtKB/Swiss-Prot:Q3TDN0

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