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Smim1 small integral membrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 68859, updated on 5-Mar-2024

Summary

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Official Symbol
Smim1provided by MGI
Official Full Name
small integral membrane protein 1provided by MGI
Primary source
MGI:MGI:1916109
See related
Ensembl:ENSMUSG00000078350 AllianceGenome:MGI:1916109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610011H04Rik; 1190007F08Rik; 2700009I11Rik
Summary
Predicted to enable protein homodimerization activity. Predicted to be located in cell surface and plasma membrane. Orthologous to human SMIM1 (small integral membrane protein 1 (Vel blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 46.8), liver E14.5 (RPKM 44.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 83.79 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154104927..154110550, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154020470..154026085, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DNA fragmentation factor, beta subunit Neighboring gene centrosomal protein 104 Neighboring gene predicted gene, 31566 Neighboring gene leucine rich repeat containing 47 Neighboring gene coiled-coil domain containing 27 Neighboring gene transformation related protein 73 Neighboring gene STARR-seq mESC enhancer starr_12227 Neighboring gene STARR-seq mESC enhancer starr_12228 Neighboring gene predicted gene, 26036

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small integral membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163721.1 → NP_001157193.1  small integral membrane protein 1

    See identical proteins and their annotated locations for NP_001157193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK004513, BC080682
    Consensus CDS
    CCDS59664.1
    UniProtKB/Swiss-Prot
    P0C8K7
    Related
    ENSMUSP00000138605.2, ENSMUST00000146054.8
    Conserved Domains (1) summary
    pfam15875
    Location:3 → 77
    DUF4731; Domain of unknown function (DUF4731)

  2. NM_001163722.1 → NP_001157194.1  small integral membrane protein 1

    See identical proteins and their annotated locations for NP_001157194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC080682, BC172044
    Consensus CDS
    CCDS59664.1
    UniProtKB/Swiss-Prot
    P0C8K7
    Related
    ENSMUSP00000138324.2, ENSMUST00000125533.9
    Conserved Domains (1) summary
    pfam15875
    Location:3 → 77
    DUF4731; Domain of unknown function (DUF4731)

  3. NM_001357248.1 → NP_001344177.1  small integral membrane protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK004513, BC080682, W57265
    Consensus CDS
    CCDS59664.1
    UniProtKB/Swiss-Prot
    P0C8K7
    Related
    ENSMUSP00000138471.2, ENSMUST00000132541.8
    Conserved Domains (1) summary
    pfam15875
    Location:3 → 77
    DUF4731; Domain of unknown function (DUF4731)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    154104927..154110550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539148.5 → XP_006539211.1  small integral membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006539211.1

    UniProtKB/Swiss-Prot
    P0C8K7
    Related
    ENSMUSP00000138448.2, ENSMUST00000145527.8
    Conserved Domains (1) summary
    pfam15875
    Location:3 → 77
    DUF4731; Domain of unknown function (DUF4731)

  2. XM_017320379.3 → XP_017175868.1  small integral membrane protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P0C8K7
    Related
    ENSMUSP00000138675.2, ENSMUST00000130175.8
    Conserved Domains (1) summary
    pfam15875
    Location:3 → 77
    DUF4731; Domain of unknown function (DUF4731)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033144.2: Suppressed sequence

    Description
    NM_001033144.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C8K7.1 GenPept UniProtKB/Swiss-Prot:P0C8K7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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