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Tulp4 TUB like protein 4 [ Mus musculus (house mouse) ]

Gene ID: 68842, updated on 21-Apr-2024

Summary

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Official Symbol
Tulp4provided by MGI
Official Full Name
TUB like protein 4provided by MGI
Primary source
MGI:MGI:1916092
See related
Ensembl:ENSMUSG00000034377 AllianceGenome:MGI:1916092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tusp; 1110057P05Rik; 2210038L17Rik
Summary
Predicted to be located in cytoplasm. Is expressed in incisor; intestine smooth muscle circular layer; nervous system; sensory organ; and vibrissa. Orthologous to human TULP4 (TUB like protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 27.4), CNS E14 (RPKM 24.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A1; 17 3.72 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (6156528..6290912)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6106253..6240637)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 Neighboring gene STARR-seq mESC enhancer starr_41712 Neighboring gene serine active site containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9051 Neighboring gene STARR-positive B cell enhancer ABC_E8652 Neighboring gene general transcription factor IIH, polypeptide 5 Neighboring gene STARR-seq mESC enhancer starr_41713 Neighboring gene fibrillarin, pseudogene 2 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41714 Neighboring gene fibrillarin pseudogene Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_41716 Neighboring gene transmembrane protein 181A Neighboring gene dynein light chain Tctex-type 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Circ-Tulp4 promotes β-cell adaptation to lipotoxicity by regulating soat1 expression. Wu L, et al. J Mol Endocrinol, 2020 Nov. PMID 33064661, Free PMC Article
  2. Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1. Planchart A, et al. Mamm Genome, 2001 Aug. PMID 11471064
  3. Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily. Li QZ, et al. Gene, 2001 Aug 8. PMID 11595174
  4. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Gurdziel K, et al. Dev Dyn, 2016 May. PMID 26930384, Free PMC Article
  5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of Tulp4 deficiency on murine embryonic development and adult phenotype.
    Title: Effects of Tulp4 deficiency on murine embryonic development and adult phenotype.
  2. Circ-Tulp4 promotes beta-cell adaptation to lipotoxicity by regulating soat1 expression.
    Title: Circ-Tulp4 promotes β-cell adaptation to lipotoxicity by regulating soat1 expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
tubby-related protein 4
Names
tubby like protein 4
tubby super-family protein
tubby superfamily protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103181.1 → NP_001096651.1  tubby-related protein 4 isoform b

    See identical proteins and their annotated locations for NP_001096651.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' terminal exon, which results in a downstream translation start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK004288, AK147643, BB641651, BP764413, BU510078, BY244468, CJ071434, CN669880, CX219752
    Consensus CDS
    CCDS49934.1
    UniProtKB/TrEMBL
    Q3UH13
    Related
    ENSMUSP00000123218.2, ENSMUST00000149756.8
    Conserved Domains (3) summary
    PHA03247
    Location:813 → 1118
    PHA03247; large tegument protein UL36; Provisional
    pfam01167
    Location:1277 → 1347
    Tub; Tub family
    cl02533
    Location:180 → 215
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  2. NM_054040.3 → NP_473381.1  tubby-related protein 4 isoform a

    See identical proteins and their annotated locations for NP_473381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AF219945, AK004288, AK039439, AK173165, BP764413, BU510078, CN669880, CX219752
    Consensus CDS
    CCDS28370.1
    UniProtKB/Swiss-Prot
    B2RQP8, Q8CA75, Q922C2, Q9JIL5
    Related
    ENSMUSP00000049248.3, ENSMUST00000039655.3
    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1470 → 1540
    Tub; Tub family
    pfam03154
    Location:925 → 1334
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    6156528..6290912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250031.1 → XP_030105891.1  tubby-related protein 4 isoform X1

    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1513 → 1583
    Tub; Tub family
    pfam03154
    Location:968 → 1377
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  2. XM_030250033.1 → XP_030105893.1  tubby-related protein 4 isoform X2

    UniProtKB/Swiss-Prot
    B2RQP8, Q8CA75, Q922C2, Q9JIL5
    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1470 → 1540
    Tub; Tub family
    pfam03154
    Location:925 → 1334
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  3. XM_030250034.1 → XP_030105894.1  tubby-related protein 4 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:856 → 1161
    PHA03247; large tegument protein UL36; Provisional
    pfam01167
    Location:1320 → 1390
    Tub; Tub family
    cl02533
    Location:180 → 215
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  4. XM_030250035.1 → XP_030105895.1  tubby-related protein 4 isoform X5

    UniProtKB/TrEMBL
    Q3UH13
    Conserved Domains (3) summary
    PHA03247
    Location:813 → 1118
    PHA03247; large tegument protein UL36; Provisional
    pfam01167
    Location:1277 → 1347
    Tub; Tub family
    cl02533
    Location:180 → 215
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  5. XM_006523248.4 → XP_006523311.1  tubby-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006523311.1

    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1513 → 1583
    Tub; Tub family
    pfam03154
    Location:968 → 1377
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  6. XM_030250032.1 → XP_030105892.1  tubby-related protein 4 isoform X2

    UniProtKB/Swiss-Prot
    B2RQP8, Q8CA75, Q922C2, Q9JIL5
    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1470 → 1540
    Tub; Tub family
    pfam03154
    Location:925 → 1334
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  7. XM_036160775.1 → XP_036016668.1  tubby-related protein 4 isoform X3

    Conserved Domains (5) summary
    PHA03247
    Location:995 → 1326
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:86 → 121
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1459 → 1529
    Tub; Tub family
    cl02533
    Location:319 → 354
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl29593
    Location:78 → 164
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_006523252.4 → XP_006523315.1  tubby-related protein 4 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:856 → 1161
    PHA03247; large tegument protein UL36; Provisional
    pfam01167
    Location:1320 → 1390
    Tub; Tub family
    cl02533
    Location:180 → 215
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  9. XM_030250028.2 → XP_030105888.1  tubby-related protein 4 isoform X1

    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1513 → 1583
    Tub; Tub family
    pfam03154
    Location:968 → 1377
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  10. XM_030250030.2 → XP_030105890.1  tubby-related protein 4 isoform X1

    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1513 → 1583
    Tub; Tub family
    pfam03154
    Location:968 → 1377
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  11. XM_030250029.2 → XP_030105889.1  tubby-related protein 4 isoform X1

    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1513 → 1583
    Tub; Tub family
    pfam03154
    Location:968 → 1377
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  12. XM_006523249.5 → XP_006523312.1  tubby-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006523312.1

    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1513 → 1583
    Tub; Tub family
    pfam03154
    Location:968 → 1377
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  13. XM_030250027.2 → XP_030105887.1  tubby-related protein 4 isoform X1

    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1513 → 1583
    Tub; Tub family
    pfam03154
    Location:968 → 1377
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  14. XM_006523251.5 → XP_006523314.1  tubby-related protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006523314.1

    UniProtKB/Swiss-Prot
    B2RQP8, Q8CA75, Q922C2, Q9JIL5
    Conserved Domains (5) summary
    COG2319
    Location:67 → 217
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85 → 123
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1470 → 1540
    Tub; Tub family
    pfam03154
    Location:925 → 1334
    Atrophin-1; Atrophin-1 family
    cl02533
    Location:373 → 408
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  15. XM_036160774.1 → XP_036016667.1  tubby-related protein 4 isoform X3

    Conserved Domains (5) summary
    PHA03247
    Location:995 → 1326
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:86 → 121
    7WD40; WD40 repeat [structural motif]
    pfam01167
    Location:1459 → 1529
    Tub; Tub family
    cl02533
    Location:319 → 354
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl29593
    Location:78 → 164
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033529.1: Suppressed sequence

    Description
    NM_001033529.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIL5.1 GenPept UniProtKB/Swiss-Prot:Q9JIL5

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