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Ankrd46 ankyrin repeat domain 46 [ Mus musculus (house mouse) ]

Gene ID: 68839, updated on 5-Mar-2024

Summary

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Official Symbol
Ankrd46provided by MGI
Official Full Name
ankyrin repeat domain 46provided by MGI
Primary source
MGI:MGI:1916089
See related
Ensembl:ENSMUSG00000048307 AllianceGenome:MGI:1916089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110054N06Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in nervous system. Orthologous to human ANKRD46 (ankyrin repeat domain 46). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 35.6), bladder adult (RPKM 34.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.1; 15 14.47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36477814..36496937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36477668..36496791, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38358 Neighboring gene predicted gene, 34150 Neighboring gene predicted gene, 34093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:36390760-36390961 Neighboring gene STARR-seq mESC enhancer starr_38360 Neighboring gene predicted gene, 34316 Neighboring gene sorting nexin 31 Neighboring gene STARR-seq mESC enhancer starr_38361 Neighboring gene STARR-seq mESC enhancer starr_38364 Neighboring gene poly(A) binding protein, cytoplasmic 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MicroRNA-451 plays a role in murine embryo implantation through targeting Ankrd46, as implicated by a microarray-based analysis. Li Z, et al. Fertil Steril, 2015 Mar. PMID 25542822
  2. Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse. Brouns MR, et al. Hum Mol Genet, 2011 Apr 15. PMID 21262862, Free PMC Article
  3. Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Silvestri C, et al. Dev Cell, 2008 Mar. PMID 18331719
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-451 was specifically up-regulated during the implantation period, and it may play a major role in embryo implantation by targeting Ankrd46.
    Title: MicroRNA-451 plays a role in murine embryo implantation through targeting Ankrd46, as implicated by a microarray-based analysis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 46
Names
ANK-S
ankyrin repeat small protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358006.1 → NP_001344935.1  ankyrin repeat domain-containing protein 46

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC137871, AC158986
    Consensus CDS
    CCDS27429.1
    UniProtKB/Swiss-Prot
    Q1LZK9, Q8BTZ5, Q8BV97
    Conserved Domains (2) summary
    COG0666
    Location:15 → 148
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:15 → 42
    ANK; ANK repeat [structural motif]

  2. NM_001358007.1 → NP_001344936.1  ankyrin repeat domain-containing protein 46

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC137871, AC158986
    Consensus CDS
    CCDS27429.1
    UniProtKB/Swiss-Prot
    Q1LZK9, Q8BTZ5, Q8BV97
    Conserved Domains (2) summary
    COG0666
    Location:15 → 148
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:15 → 42
    ANK; ANK repeat [structural motif]

  3. NM_175134.4 → NP_780343.1  ankyrin repeat domain-containing protein 46

    See identical proteins and their annotated locations for NP_780343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC035553, BQ715954
    Consensus CDS
    CCDS27429.1
    UniProtKB/Swiss-Prot
    Q1LZK9, Q8BTZ5, Q8BV97
    Related
    ENSMUSP00000052521.8, ENSMUST00000057486.9
    Conserved Domains (2) summary
    COG0666
    Location:15 → 148
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:15 → 42
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    36477814..36496937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTZ5.1 GenPept UniProtKB/Swiss-Prot:Q8BTZ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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