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Foxk2 forkhead box K2 [ Mus musculus (house mouse) ]

Gene ID: 68837, updated on 5-Mar-2024

Summary

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Official Symbol
Foxk2provided by MGI
Official Full Name
forkhead box K2provided by MGI
Primary source
MGI:MGI:1916087
See related
Ensembl:ENSMUSG00000039275 AllianceGenome:MGI:1916087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ILF; Ilf1; 1110054H05Rik; 5730434B08Rik; 6230415M23Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including blastocyst; genitourinary system; and nervous system. Orthologous to human FOXK2 (forkhead box K2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 17.4), ovary adult (RPKM 17.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Foxk2 in Genome Data Viewer
Location:
11 E2; 11 85.15 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121150805..121200726)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121259987..121309900)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hexosaminidase D Neighboring gene STARR-positive B cell enhancer ABC_E5315 Neighboring gene STARR-seq mESC enhancer starr_31378 Neighboring gene STARR-positive B cell enhancer ABC_E8883 Neighboring gene cytochrome b 245 chaperone 1 Neighboring gene nuclear prelamin A recognition factor Neighboring gene WD repeat domain 45B Neighboring gene Rab40B, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_31380 Neighboring gene microRNA 7236

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FoxK2 is required for cellular proliferation and survival. van der Heide LP, et al. J Cell Physiol, 2015 May. PMID 25216324
  2. FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Sakaguchi M, et al. Nat Commun, 2019 Apr 5. PMID 30952843, Free PMC Article
  3. CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner. Xu Q, et al. Int J Biol Sci, 2021. PMID 34239356, Free PMC Article
  4. FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus. Wang W, et al. Dev Cell, 2015 Mar 23. PMID 25805136, Free PMC Article
  5. Identification of transcriptionally regulated mRNAs from mouse Schwann cell precursors using modified RNA fingerprinting methods. Zoidl G, et al. J Neurosci Res, 1997 Jul 1. PMID 9211987

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner.
    Title: CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner.
  2. in vitro and in vivo experiments, including studies of primary human cells, show how FOXK1 and/or FOXK2 are likely to act as important regulators that reprogram cellular metabolism to induce aerobic glycolysis
    Title: FOXK1 and FOXK2 regulate aerobic glycolysis.
  3. FoxK1/K2 are reciprocally regulated to FoxO1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function.
    Title: FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.
  4. FoxK2 is required for proliferation and survival.
    Title: FoxK2 is required for cellular proliferation and survival.
  5. Foxk1 and Foxk2 are identified as transcriptional repressors of autophagy in muscle cells and fibroblasts.
    Title: Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of canonical glycolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular glucose homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
forkhead box protein K2
Names
cellular transcription factor ILF-1
interleukin enhancer-binding factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080932.3 → NP_001074401.2  forkhead box protein K2 isoform 1

    See identical proteins and their annotated locations for NP_001074401.2

    Status: VALIDATED

    Source sequence(s)
    AL808021, EU882160
    Consensus CDS
    CCDS36393.2
    UniProtKB/Swiss-Prot
    A2AN27, B5AZX0, Q3UCQ1
    Related
    ENSMUSP00000101719.2, ENSMUST00000106113.2
    Conserved Domains (2) summary
    cd00060
    Location:41 → 145
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:249 → 335
    Forkhead; Forkhead domain

  2. NM_001363033.1 → NP_001349962.1  forkhead box protein K2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK150439, AL808021
    Conserved Domains (2) summary
    cd00060
    Location:41 → 145
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:249 → 334
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    121150805..121200726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156941.1 → XP_036012834.1  forkhead box protein K2 isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:341 → 562
    PHA03247; large tegument protein UL36; Provisional
    cd00060
    Location:41 → 145
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd20055
    Location:247 → 344
    FH_FOXK2; Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins

  2. XM_036156942.1 → XP_036012835.1  forkhead box protein K2 isoform X6

    Conserved Domains (2) summary
    cd00060
    Location:41 → 145
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd20055
    Location:247 → 344
    FH_FOXK2; Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins

  3. XM_011249218.2 → XP_011247520.1  forkhead box protein K2 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:380 → 683
    PHA03247; large tegument protein UL36; Provisional
    COG5025
    Location:175 → 381
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:41 → 124
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:287 → 373
    Forkhead; Forkhead domain

  4. XM_011249219.2 → XP_011247521.1  forkhead box protein K2 isoform X2

    Conserved Domains (4) summary
    PHA03247
    Location:380 → 657
    PHA03247; large tegument protein UL36; Provisional
    COG5025
    Location:175 → 381
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:41 → 124
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:287 → 373
    Forkhead; Forkhead domain

  5. XM_011249220.2 → XP_011247522.1  forkhead box protein K2 isoform X4

    Conserved Domains (3) summary
    COG5025
    Location:175 → 381
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:41 → 124
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:287 → 373
    Forkhead; Forkhead domain

  6. XM_011249221.2 → XP_011247523.1  forkhead box protein K2 isoform X5

    Conserved Domains (3) summary
    COG5025
    Location:175 → 381
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:41 → 124
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:287 → 373
    Forkhead; Forkhead domain

RNA

  1. XR_004937017.1 RNA Sequence

  2. XR_003949496.2 RNA Sequence

  3. XR_004937014.1 RNA Sequence

  4. XR_879734.2 RNA Sequence

  5. XR_004937015.1 RNA Sequence

  6. XR_003949497.2 RNA Sequence

  7. XR_004937016.1 RNA Sequence

  8. XR_004937018.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UCQ1.3 GenPept UniProtKB/Swiss-Prot:Q3UCQ1

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